KRT5 and KRT7

Number of citations of the paper that reports this interaction (PubMedID 35575683)
0

Data Source:
BioGRID (cross-linking study)

		KRT5	KRT7
Description		keratin 5	keratin 7
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Scaffold Protein Binding	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Epidermis Development Response To Mechanical Stimulus Regulation Of Cell Migration Keratinization Regulation Of Protein Localization Intermediate Filament Polymerization Intermediate Filament Organization	Keratinization Intermediate Filament Organization
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Keratinization Formation of the cornified envelope Developmental Lineage of Pancreatic Ductal Cells
Drugs		Zinc Zinc acetate	Primaquine Verpasep caltespen
Diseases		Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dowling-Degos disease
GWAS		Basal cell carcinoma ( 24403052 25855136 27539887 31174203 33549134) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)	Blond vs. brown/black hair color ( 30531825) Diisocyanate-induced asthma ( 25918132)
Interacting Genes		40 interacting genes: ALOX12 ALOX12B APC DCTN1 DSP DST EVPL GPD1 INCA1 KIFC3 KRT1 KRT13 KRT14 KRT15 KRT18 KRT24 KRT25 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT4 KRT40 KRT6A KRT6B KRT7 NADSYN1 PKP2 RNF26 SAP18 SORD TARBP2 TCHP UBE3A	13 interacting genes: ATF7IP EGFR HMGB1 HSPA1A KDM1A KRT13 KRT17 KRT27 KRT5 KRT6A LAPTM5 LINC01554 UBE3A
Entrez ID		3852	3855
HPRD ID		01010	01014
Ensembl ID		ENSG00000186081	ENSG00000135480
Uniprot IDs		P13647	P08729
PDB IDs		3TNU 6JFV	4XIF
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Tissue Morphogenesis Epithelial Cell Differentiation Morphogenesis Of An Epithelium Cytoskeleton Organelle Organization Extracellular Exosome Cytosol Anatomical Structure Morphogenesis Epidermis Development Intermediate Filament Cytoskeleton Developmental Process Keratinization Cellular Developmental Process Cell Differentiation Structural Constituent Of Cytoskeleton Cornified Envelope Tissue Development Desmosome Hair Cycle Peptide Cross-linking Arachidonate 12(S)-lipoxygenase Activity Wound Healing Anchoring Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Hair Follicle Morphogenesis Adherens Junction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Establishment Of Skin Barrier Hepoxilin Biosynthetic Process Polymeric Cytoskeletal Fiber Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Skin Epidermis Development Intermediate Filament Bundle Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Lipoxygenase Pathway Negative Regulation Of Cyclin-dependent Protein Kinase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Regulation Of Ventricular Cardiac Muscle Cell Action Potential Keratinocyte Differentiation Desmosome Organization Scaffold Protein Binding	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Morphogenesis Of An Epithelium Tissue Morphogenesis Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Transcription Corepressor Activity Keratinization Hair Cycle Process Regulation Of Post-translational Protein Modification Supramolecular Fiber Organization Regulation Of Protein Metabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Protein Modification Process Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Positive Regulation Of Biosynthetic Process Hair Follicle Morphogenesis Regulation Of Ubiquitin-dependent Protein Catabolic Process Structural Molecule Activity Regulation Of Activated T Cell Proliferation Negative Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Cell Population Proliferation Cell Differentiation Regulation Of DNA Repair Multivesicular Body, Internal Vesicle Lumen Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Response To Steroid Hormone Positive Regulation Of Myeloid Progenitor Cell Differentiation Intermediate Filament Polymerization Cytoskeleton Organization Intermediate Filament Cytoskeleton Sperm Entry Positive Regulation Of Golgi Lumen Acidification Induction Of Programmed Cell Death Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Lysosomal Membrane Permeability Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
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