KRT5 and ALOX12

Number of citations of the paper that reports this interaction (PubMedID 10727209)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo)

		KRT5	ALOX12
Description		keratin 5	arachidonate 12-lipoxygenase, 12S type
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Cytoplasm Cytosol Membrane Sarcolemma Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Scaffold Protein Binding	Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Metal Ion Binding Hepoxilin-epoxide Hydrolase Activity Arachidonate 15-lipoxygenase Activity Dioxygenase Activity
	Biological Process	Epidermis Development Response To Mechanical Stimulus Regulation Of Cell Migration Keratinization Regulation Of Protein Localization Intermediate Filament Polymerization Intermediate Filament Organization	Lipid Metabolic Process Fatty Acid Metabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Arachidonate Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Unsaturated Fatty Acid Metabolic Process Lipid Oxidation Superoxide Anion Generation Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Hepoxilin Biosynthetic Process Establishment Of Skin Barrier Negative Regulation Of Platelet Aggregation Leukotriene A4 Metabolic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Biosynthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Biosynthesis of DHA-derived SPMs Biosynthesis of DPAn-6 SPMs Biosynthesis of DPAn-3-derived maresins
Drugs		Zinc Zinc acetate
Diseases		Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dowling-Degos disease
GWAS		Basal cell carcinoma ( 24403052 25855136 27539887 31174203 33549134) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)	Mean platelet volume ( 32888494)
Interacting Genes		40 interacting genes: ALOX12 ALOX12B APC DCTN1 DSP DST EVPL GPD1 INCA1 KIFC3 KRT1 KRT13 KRT14 KRT15 KRT18 KRT24 KRT25 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT4 KRT40 KRT6A KRT6B KRT7 NADSYN1 PKP2 RNF26 SAP18 SORD TARBP2 TCHP UBE3A	7 interacting genes: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1
Entrez ID		3852	239
HPRD ID		01010	01066
Ensembl ID		ENSG00000186081	ENSG00000108839
Uniprot IDs		P13647	P18054
PDB IDs		3TNU 6JFV	3D3L 8GHB 8GHC 8GHD 8GHE
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Tissue Morphogenesis Epithelial Cell Differentiation Morphogenesis Of An Epithelium Cytoskeleton Organelle Organization Extracellular Exosome Cytosol Anatomical Structure Morphogenesis Epidermis Development Intermediate Filament Cytoskeleton Developmental Process Keratinization Cellular Developmental Process Cell Differentiation Structural Constituent Of Cytoskeleton Cornified Envelope Tissue Development Desmosome Hair Cycle Peptide Cross-linking Arachidonate 12(S)-lipoxygenase Activity Wound Healing Anchoring Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Hair Follicle Morphogenesis Adherens Junction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Establishment Of Skin Barrier Hepoxilin Biosynthetic Process Polymeric Cytoskeletal Fiber Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Skin Epidermis Development Intermediate Filament Bundle Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Lipoxygenase Pathway Negative Regulation Of Cyclin-dependent Protein Kinase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Regulation Of Ventricular Cardiac Muscle Cell Action Potential Keratinocyte Differentiation Desmosome Organization Scaffold Protein Binding	Intermediate Filament Phosphatidylethanolamine Metabolic Process Peripheral Nervous System Myelin Formation Structural Constituent Of Cytoskeleton Intermediate Filament Polymerization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament Polymerization Or Depolymerization Keratinization Keratin Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization DNA Double-strand Break Attachment To Nuclear Envelope Nuclear Lumen Site Of Double-strand Break Negative Regulation Of Multicellular Organismal Process Structural Constituent Of Nuclear Lamina Cellular Senescence Phosphatidylcholine Metabolic Process Positive Regulation Of Eosinophil Differentiation Negative Regulation Of Neutrophil Differentiation Histone H2AK5 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Epidermis Development Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Piccolo Histone Acetyltransferase Complex Hemidesmosome Assembly Nail Development Neuregulin Binding Tissue Development Structural Molecule Activity Negative Regulation Of Cell Population Proliferation Lamin Filament Perinuclear Region Of Cytoplasm Nuclear Pore Localization Intestinal Stem Cell Homeostasis Ubiquitin-protein Transferase Regulator Activity Positive Regulation Of Protein Acetylation Positive Regulation Of Aggrephagy Positive Regulation Of Leukocyte Differentiation Trophoblast Cell Migration Lipid Droplet Disassembly Hemidesmosome Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Granulocyte Differentiation
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