KLRD1 and HLA-G

Number of citations of the paper that reports this interaction (PubMedID 9405670)
29

Data Source:
HPRD (in vivo)

		KLRD1	HLA-G
Description		killer cell lectin like receptor D1	major histocompatibility complex, class I, G
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Golgi Membrane Extracellular Region Extracellular Space Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Filopodium Membrane Early Endosome Membrane Cis-Golgi Network Membrane MHC Class I Protein Complex Cell Projection Recycling Endosome Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding MHC Class Ib Protein Binding, Via Antigen Binding Groove Carbohydrate Binding HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding	Signaling Receptor Binding Protein Binding Peptide Antigen Binding CD8 Receptor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Activation Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Peripheral B Cell Tolerance Induction Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response Cellular Defense Response Negative Regulation Of Angiogenesis Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Protection From Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Immune Response Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Negative Regulation Of G0 To G1 Transition Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of Dendritic Cell Differentiation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Umami taste perception in obesity with metabolic syndrome ( 31005965)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Childhood ear infection ( 27182965) Colorectal cancer ( 30529582) Crohn's disease ( 22412388) Eosinophil percentage of white cells ( 32888494) Glaucoma (primary open-angle) ( 33627673) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) IgE levels ( 22075330) IgM levels ( 28628107) LDL cholesterol levels ( 32203549) Lung adenocarcinoma ( 28604730) Lung cancer ( 31577861) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533 33308445) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: HLA-B HLA-E HLA-G KLRC1 KLRC2 KLRC3	11 interacting genes: B2M CD8A CDC42 COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2 TH
Entrez ID		3824	3135
HPRD ID		04204	00834
Ensembl ID		ENSG00000134539	ENSG00000204632
Uniprot IDs		F6WZH4 Q13241 Q53ZY6	A0A0G2JNX1 P17693 Q31611 Q5RJ85 Q6DU14 Q8MH48
PDB IDs		1B6E 3BDW 3CDG 3CII	1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO 6AEE 6K60
Enriched GO Terms of Interacting Partners?		Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Immune Effector Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity External Side Of Plasma Membrane Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Innate Immune Response Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity MHC Class I Protein Complex Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Adaptive Immune Response Positive Regulation Of Innate Immune Response Regulation Of Defense Response Negative Regulation Of Innate Immune Response Regulation Of T Cell Mediated Immunity Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Defense Response Antigen Processing And Presentation Of Endogenous Antigen Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Defense Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Regulation Of Cell Activation Cellular Defense Response Regulation Of Immune System Process ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immunity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway	MHC Class Ib Protein Binding Adaptive Immune Response MHC Class I Protein Binding Regulation Of Leukocyte Mediated Cytotoxicity MHC Class I Peptide Loading Complex Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Lymphocyte Mediated Immunity Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex MHC Class Ib Protein Complex Binding Positive Regulation Of Immune Effector Process Regulation Of Immune Response Regulation Of T Cell Mediated Immunity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Lymphocyte Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity ABC-type Peptide Transporter Activity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Mediated Immunity Peptide Antigen Binding Positive Regulation Of Immune Response Leukocyte Mediated Immunity Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib TAP1 Binding Immune System Process Immune Effector Process Immune Response-regulating Signaling Pathway Cytosol To Endoplasmic Reticulum Transport Fc Receptor Mediated Inhibitory Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity MHC Class Ib Receptor Activity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Adaptive Immune Response MHC Class I Protein Complex Binding MHC Protein Binding Inhibitory MHC Class I Receptor Activity Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Immune System Process Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
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