KLRC2 and FBP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		KLRC2	FBP1
Description		killer cell lectin like receptor C2	fructose-bisphosphatase 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding MHC Class Ib Receptor Activity Activating MHC Class Ib Receptor Activity Protein Antigen Binding	Catalytic Activity Protein Binding AMP Binding Hydrolase Activity Phosphatase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Phosphoric Ester Hydrolase Activity Identical Protein Binding Metal Ion Binding Monosaccharide Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Defense Response Signal Transduction Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Degranulation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Negative Regulation Of Transcription By RNA Polymerase II Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Negative Regulation Of Cell Growth Fructose 1,6-bisphosphate Metabolic Process Response To Nutrient Levels Cellular Response To Insulin Stimulus Negative Regulation Of Glycolytic Process Negative Regulation Of Ras Protein Signal Transduction Cellular Response To Magnesium Ion Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Cellular Hyperosmotic Salinity Response Cellular Hypotonic Salinity Response Cellular Response To Raffinose Cellular Response To Phorbol 13-acetate 12-myristate
Pathways		DAP12 interactions DAP12 signaling DAP12 signaling	Gluconeogenesis
Drugs			Adenosine phosphate 2,5-Anhydroglucitol-1,6-Biphosphate {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol Mdl-29951 Fructose-6-phosphate MB-07803 Managlinat dialanetil N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE
Diseases			Fructose-1,6-bisphosphatase deficiency
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494)	Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Colorectal or endometrial cancer ( 26621817) Obesity-related traits ( 23251661)
Interacting Genes		5 interacting genes: FBP1 FGF6 HLA-E KLRD1 NIF3L1	40 interacting genes: ACTN1 APC ASCC2 ASL ATP5MF AXIN2 BCL10 BCL2L1 BIN1 BMPR1A BRAF BUB1 CSNK1E CTNNA1 DCC DNMT1 DYNC1I1 ERBB2 FLCN FXR2 HDAC6 HSPA8 KLRC2 LNX1 MLH3 MSH2 NOTCH1 PCNX4 PIM2 POT1 PRKN PTK2 PTPRJ RB1 RELA RNF183 STK11 TERF1 TLR2 TRIM28
Entrez ID		3822	2203
HPRD ID		04202	01973
Ensembl ID		ENSG00000205809	ENSG00000165140
Uniprot IDs		P26717	P09467 Q2TU34
PDB IDs		2L35	1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B 5ZWK 6LS5 6LW2 7C9Q 7CVH 7CVN 7CWE 7EZF 7EZP 7EZR 7WJV 7WVB 8XBK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity Regulation Of T Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Lymphocyte Mediated Immunity MHC Class Ib Protein Complex Positive Regulation Of TRAIL Production HLA-E Specific Inhibitory MHC Class Ib Receptor Activity MHC Class Ib Protein Binding, Via Antigen Binding Groove Leukocyte Mediated Immunity Cellular Hypotonic Salinity Response Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Regulation Of TRAIL Production Natural Killer Cell Tolerance Induction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Type IIa Hypersensitivity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Lymphocyte Mediated Immunity Cellular Hyperosmotic Salinity Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Hyperosmotic Salinity Response Cellular Response To Magnesium Ion Protection From Natural Killer Cell Mediated Cytotoxicity Monosaccharide Binding Positive Regulation Of Hypersensitivity MHC Class I Protein Complex Binding Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Beta-2-microglobulin Binding Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of Immune Effector Process MHC Class I Protein Complex	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Nervous System Development Regulation Of Neurogenesis Positive Regulation Of Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Cell Development Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nervous System Development Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Regulation Of Primary Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Regulation Of Protein Localization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Beta-catenin Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Protein Modification Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Anatomical Structure Morphogenesis Positive Regulation Of Catabolic Process Regulation Of Phosphorylation Apoptotic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Neurogenesis Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Positive Regulation Of Neurogenesis Programmed Cell Death Regulation Of Growth Cell Death
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