KIR2DL4 and TRIP6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KIR2DL4	TRIP6
Description		killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	thyroid hormone receptor interactor 6
Image
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Early Endosome Membrane	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Anchoring Junction
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class Ib Receptor Activity	RNA Binding Interleukin-1 Receptor Binding Protein Binding Kinase Binding Metal Ion Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response-regulating Signaling Pathway Cellular Defense Response Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cellular Senescence	Cell Adhesion Signal Transduction Positive Regulation Of Cell Migration Chordate Embryonic Development Focal Adhesion Assembly Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Objective response to lithium treatment ( 26503763)	Bipolar disorder ( 31043756) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		9 interacting genes: BPIFA1 FCER1G FHL5 HLA-G INCA1 RBPMS RNF216 TIMMDC1 TRIP6	165 interacting genes: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP23 ATP5PO ATXN1 AXIN1 BAG3 BCAR1 BEX2 BYSL C11orf87 CATSPER1 CBLC CCDC120 CCDC187 CCDC24 CCL5 CEP57L1 CNTF CREB5 CRYBA4 CTAG2 DHX37 DMRT3 DTX2 EFHC1 EPDR1 ERBB2 EXOC3-AS1 FAM124B FAM222B FARS2 FAS FASLG FHL3 FOXD4L1 FRS3 GAD1 GATA1 GFI1B GLIS3 GNAI2 GNE GPS2 GSE1 HCK HLA-DPB1 HOXA1 HOXA9 HOXB9 HOXC8 HYKK IL16 ILF3 INCA1 IP6K3 IQCN ITGB4 KCTD9 KIF1A KIR2DL4 KLK15 KPRP KRTAP26-1 LMO2 LNX1 LPAR2 MAPKBP1 MEMO1 METTL17 MIEN1 MIIP MISP MSRB3 MVP NCK2 NEDD9 NEU4 NOL4L-DT NR1D2 NSMF NUP210 ODF1 OIP5 OTUB2 OTX1 PATZ1 PDGFRB PDLIM4 PER1 PIGS PIN1 PLEKHN1 POM121 POM121L4P PPDPF PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PTPN14 PXN RAD23A RANBP3L RELN RERE RFX3 RHOA RHOQ RNF213 RNF214 SAXO1 SCAND1 SCRIB SETDB1 SHISA6 SIK3 SLC25A6 SMAD1 SMG9 SNAI1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TBC1D22B TCAF1 TEKT4 TENT5C THRB TIE1 TLE5 TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TSGA10IP TSSK3 TTC23 TTLL10 TXN2 TXNDC5 USP2 VASN VCL WT1-AS YAP1 YPEL3 ZBP1 ZIC1 ZNF541 ZNF580 ZNF581 ZNF688 ZNF785
Entrez ID		3805	7205
HPRD ID		16082	04242
Ensembl ID		ENSG00000189013	ENSG00000087077
Uniprot IDs		A0A0B4J1S6 A0A376A929 Q99706	Q15654
PDB IDs		3WYR	1X61 2DLO
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Type I Hypersensitivity Antigen Processing And Presentation Mast Cell Apoptotic Process Serotonin Secretion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Cytokine Production Involved In Immune Response B Cell Mediated Immunity Negative Regulation Of Mast Cell Apoptotic Process IgE Receptor Activity Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Serotonin Secretion By Platelet Regulation Of Cytokine Production Involved In Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Positive Regulation Of Lymphocyte Mediated Immunity Lymphocyte Mediated Immunity Fc-gamma Receptor III Complex Positive Regulation Of Adaptive Immune Response Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity CD8 Receptor Binding Tolerance Induction Dependent Upon Immune Response Peripheral B Cell Tolerance Induction MRNA CDS Binding Immune Response In Nasopharyngeal-associated Lymphoid Tissue Immune Response In Gut-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Leukocyte Mediated Immunity Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Protection From Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Negative Regulation Of G0 To G1 Transition Negative Regulation Of Dendritic Cell Differentiation Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation	Protein Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Complex Assembly Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Metabolic Process Focal Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Stress Fiber Actin Filament Cell Motility Positive Regulation Of Macromolecule Metabolic Process Anchoring Junction Positive Regulation Of RNA Metabolic Process Actin Filament Organization Sequence-specific Double-stranded DNA Binding Cell Migration Nucleus Cytoskeleton Necroptotic Signaling Pathway Cytoplasm Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity ERBB Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transcription Regulator Complex Anatomical Structure Morphogenesis Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Mesoderm Development Positive Regulation Of TOR Signaling Positive Regulation Of Locomotion Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Protein Tyrosine Kinase Activity Cold Acclimation Regulation Of RNA Metabolic Process Regulation Of Podosome Assembly Supramolecular Fiber Organization Regulation Of Cell Motility Positive Regulation Of Cell Migration Cell Cortex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?