ARL4D and EML4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARL4D	EML4
Description		ARF like GTPase 4D	EMAP like 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Plasma Membrane Membrane	Cytoplasm Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Membrane Midbody Intercellular Bridge Mitotic Spindle
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Protein Binding Microtubule Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Intracellular Protein Transport Protein Secretion Vesicle-mediated Transport	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Mitotic Metaphase Chromosome Alignment Attachment Of Spindle Microtubules To Kinetochore Cell Division
Pathways			EML4 and NUDC in mitotic spindle formation ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases			Non-small cell lung cancer
GWAS			Chronic obstructive pulmonary disease ( 30804561) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 30061609) Metabolite levels ( 23823483) PR interval ( 32439900) Type 2 diabetes ( 31118516)
Interacting Genes		22 interacting genes: APP ARL6IP1 CCDC102B CNPY4 CYTH2 DNAJA1 EIF2B1 EML4 EPRS1 MAPK8IP3 NDRG1 PGAM1 PRKCSH SMAD1 SMAD2 SMURF1 SNRPN TGFBR1 TLE1 TMEM230 UBR1 UNC119	7 interacting genes: ARIH2 ARL4D MTCH1 NEK6 NEK7 TUBA1B TUBB
Entrez ID		379	27436
HPRD ID		02842	06310
Ensembl ID		ENSG00000175906	ENSG00000143924
Uniprot IDs		P49703	B5MBZ0 Q9HC35
PDB IDs			4CGC
Enriched GO Terms of Interacting Partners?		I-SMAD Binding Homomeric SMAD Protein Complex SMAD Protein Complex SMAD Binding Trophoblast Cell Migration Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Co-SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Primary MiRNA Processing Axo-dendritic Transport Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Response To Growth Factor Protein Serine/threonine Kinase Binding Cytosol Cytoplasm Ubiquitin Protein Ligase Binding SMAD Protein Signal Transduction Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Response To Cholesterol R-SMAD Binding Growth Cone Regulation Of JNK Cascade MiRNA Processing Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Proline-tRNA Ligase Activity Prolyl-tRNA Aminoacylation Ureteric Bud Development Engulfment Of Target By Autophagosome Transport Along Microtubule	Microtubule Spindle Assembly Microtubule Cytoskeleton Organization Spindle Organization Nucleotide Binding Ubiquitin Protein Ligase Binding Microtubule-based Process Membraneless Organelle Assembly GTPase Activity GTP Binding Cytoskeleton Organization Cell Division Structural Constituent Of Cytoskeleton Protein Localization To Extracellular Region Protein Secretion Establishment Of Protein Localization To Extracellular Region Organelle Organization Mitotic Cell Cycle Cytoskeleton Cellular Localization Establishment Of Localization In Cell Spindle Pole Structural Molecule Activity Organelle Assembly Cytoskeleton-dependent Intracellular Transport Odontoblast Differentiation Microtubule Cytoskeleton Mitotic Nuclear Membrane Disassembly Regulation Of Chromosome Organization Neuronal Ion Channel Clustering Positive Regulation Of Interleukin-18 Production GTPase Activating Protein Binding Nuclear Envelope Lumen Protein Insertion Into Mitochondrial Outer Membrane Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Cellular Response To Potassium Ion Cul5-RING Ubiquitin Ligase Complex Nuclear Membrane Disassembly Membrane Disassembly Membrane Insertase Activity MHC Class I Protein Binding
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