MALAT1 and CCAR2

Number of citations of the paper that reports this interaction (PubMedID 28973437)
52

Data Source:
BioGRID (unspecified method)

		MALAT1	CCAR2
Description		metastasis associated lung adenocarcinoma transcript 1	cell cycle and apoptosis regulator 2
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Spindle Cytoskeleton DBIRD Complex
	Molecular Function		Adenyl-nucleotide Exchange Factor Activity RNA Polymerase II Complex Binding RNA Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding Unfolded Protein Binding
	Biological Process	Positive Regulation Of Cell Motility	Regulation Of DNA-templated Transcription MRNA Processing Apoptotic Process DNA Damage Response RNA Splicing Response To UV Wnt Signaling Pathway Negative Regulation Of Cell Growth Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Elongation Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Deacetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of DNA Damage Checkpoint
Pathways			Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Glaucoma ( 31959993) Hip circumference adjusted for BMI ( 25673412 34021172)	Haemorrhoidal disease ( 33888516)
Interacting Genes		6 interacting genes: CCAR2 FBXW7 HMGB1 KHSRP LIG3 PARP1	20 interacting genes: AR BAG2 CEBPA FMR1 FXR1 FXR2 HTRA2 IKBKB MAILR MALAT1 MYC NLGN3 RNF10 SIAH2 SIRT1 SUCLG1 SUMO2 TRIM28 WDR3 ZNF335
Entrez ID		378938	57805
HPRD ID			09159
Ensembl ID		ENSG00000251562	ENSG00000158941
Uniprot IDs			Q8N163
PDB IDs			8EZ6
Enriched GO Terms of Interacting Partners?		DNA Damage Response Nucleic Acid Metabolic Process Mitochondrial DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Circadian Rhythm Mitochondrial DNA Metabolic Process Positive Regulation Of Programmed Cell Death Response To UV DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress V(D)J Recombination Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Double-strand Break Repair DNA Metabolic Process DNA Recombination Mitochondrion Organization Base-excision Repair Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Somatic Cell DNA Recombination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Light Stimulus Nucleoplasm Chromosome Organization Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Damaged DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity Response To Radiation NAD+-protein-tyrosine ADP-ribosyltransferase Activity Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of Mitochondrial DNA Replication DNA Ligase III-XRCC1 Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Organelle Organization	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Translation Regulator Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Development Positive Regulation Of Catabolic Process Regulation Of Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Presynapse Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Developmental Process Regulation Of Nervous System Development Negative Regulation Of Metabolic Process RNA Strand Annealing Activity Positive Regulation Of Nervous System Development Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Molecular Condensate Scaffold Activity Intracellular Membraneless Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Protein Heterodimerization Activity Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ubiquitin-dependent Protein Catabolic Process Euchromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Neurogenesis Protein Catabolic Process Regulation Of Protein Catabolic Process
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