KCNJ4 and DPYD

		KCNJ4	DPYD
Description		potassium inwardly rectifying channel subfamily J member 4	dihydropyrimidine dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Monoatomic Ion Channel Complex Synapse Postsynaptic Membrane	Cytoplasm Cytosol
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding PDZ Domain Binding	Nucleotide Binding Uracil Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process CMP Catabolic Process DCMP Catabolic Process Beta-alanine Biosynthetic Process UMP Catabolic Process DUMP Catabolic Process
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Pyrimidine catabolism
Drugs		Ranolazine Miconazole Carvedilol Dronedarone	(5S)-5-Iododihydro-2,4(1H,3H)-pyrimidinedione NADPH 6-Carboxymethyluracil Flavin adenine dinucleotide Flavin mononucleotide Uracil Eniluracil 5-Iodouracil Gimeracil Tegafur-uracil
Diseases			Dihydropyrimidine dehydrogenase deficiency
GWAS		Automobile speeding propensity ( 30643258) Chronotype ( 30696823) Conotruncal heart defects ( 24800985) TPE interval (resting) ( 32386560)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 29273807 25673413) Borderline personality disorder ( 28632202) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Daytime nap ( 33568662) Extremely high intelligence ( 29520040) Face memory ( 31596458) Feeling nervous ( 29500382) Gastroesophageal reflux disease ( 31527586) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Irritable mood ( 29500382) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Platelet count ( 21507922) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 30285260 29483656 25056061 23974872 22688191) Serum metabolite levels ( 33031748) Sleep duration ( 30531941) Sleep duration (short sleep) ( 30846698) Triglyceride levels ( 32154731 32203549) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		11 interacting genes: CASK DLG1 DLG2 DLG4 GNGT2 GPR35 IL16 KCNJ2 LIN7B PRKCD SNTA1	3 interacting genes: CLK1 GOPC LXN
Entrez ID		3761	1806
HPRD ID		02738	02036
Ensembl ID		ENSG00000168135	ENSG00000188641
Uniprot IDs		P48050 Q58F07	Q12882
PDB IDs		3GJ9
Enriched GO Terms of Interacting Partners?		Regulation Of Metal Ion Transport GMP Kinase Activity GDP Metabolic Process Regulation Of Monoatomic Ion Transport Nucleoside Monophosphate Metabolic Process Neuromuscular Junction Postsynaptic Density Membrane GMP Metabolic Process Ionotropic Glutamate Receptor Binding Regulation Of Transport Plasma Membrane MPP7-DLG1-LIN7 Complex Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Cell-cell Junction Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Basolateral Plasma Membrane Ribonucleoside Diphosphate Metabolic Process Voltage-gated Potassium Channel Complex Nucleoside Diphosphate Metabolic Process Protein Localization To Cell Junction Regulation Of Monoatomic Cation Transmembrane Transport Juxtaparanode Region Of Axon Regulation Of Monoatomic Ion Transmembrane Transport Ribonucleotide Metabolic Process Cellular Response To Potassium Ion Ribose Phosphate Metabolic Process Kinase Binding Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Membrane Repolarization During Cardiac Muscle Cell Action Potential Response To Potassium Ion Membrane Repolarization During Action Potential Nucleotide Metabolic Process Membrane Repolarization Establishment Or Maintenance Of Cell Polarity Regulation Of Membrane Potential Regulation Of Cardiac Muscle Cell Contraction Protein Kinase Binding Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Purine-containing Compound Metabolic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of Monoatomic Ion Transport Synapse Adherens Junction Regulation Of Membrane Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?