DPYD and LXN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DPYD	LXN
Description		dihydropyrimidine dehydrogenase	latexin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Space Cytoplasm
	Molecular Function	Nucleotide Binding Uracil Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Heparin Binding Peptidase Inhibitor Activity
	Biological Process	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process CMP Catabolic Process DCMP Catabolic Process Beta-alanine Biosynthetic Process UMP Catabolic Process DUMP Catabolic Process	Inflammatory Response Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Pathways		Pyrimidine catabolism
Drugs		(5S)-5-Iododihydro-2,4(1H,3H)-pyrimidinedione NADPH 6-Carboxymethyluracil Flavin adenine dinucleotide Flavin mononucleotide Uracil Eniluracil 5-Iodouracil Gimeracil Tegafur-uracil
Diseases		Dihydropyrimidine dehydrogenase deficiency
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 29273807 25673413) Borderline personality disorder ( 28632202) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Daytime nap ( 33568662) Extremely high intelligence ( 29520040) Face memory ( 31596458) Feeling nervous ( 29500382) Gastroesophageal reflux disease ( 31527586) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Irritable mood ( 29500382) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Platelet count ( 21507922) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 30285260 29483656 25056061 23974872 22688191) Serum metabolite levels ( 33031748) Sleep duration ( 30531941) Sleep duration (short sleep) ( 30846698) Triglyceride levels ( 32154731 32203549) Waist-to-hip ratio adjusted for BMI ( 28552196)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)
Interacting Genes		3 interacting genes: CLK1 GOPC LXN	25 interacting genes: BOC CA3 COX6A1 CYBC1 DNAJC11 DPYD FCGR3A GSG1L IGSF11 MAGEA8 MCMDC2 NSMF PAX6 PPP1R3C RNF4 SHKBP1 SPAG7 TMEM14A TRAIP TRIM39 YIF1B ZCCHC17 ZKSCAN4 ZNF430 ZNF679
Entrez ID		1806	56925
HPRD ID		02036	14327
Ensembl ID		ENSG00000188641	ENSG00000079257
Uniprot IDs		Q12882	Q9BS40
PDB IDs			2BO9
Enriched GO Terms of Interacting Partners?
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