SIMC1 and TUBA4A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		SIMC1	TUBA4A
Description		SUMO interacting motifs containing 1	tubulin alpha 4a
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm PML Body Sarcomere	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Peptidase Inhibitor Activity SUMO Polymer Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding Metal Ion Binding
	Biological Process		Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process
Pathways			Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate
Diseases
GWAS			Platelet distribution width ( 27863252 32888494) Severe autoimmune type 2 diabetes ( 34737425)
Interacting Genes		7 interacting genes: CSNK2B DNAJB11 PLK1 SUMO2 TUBA4A YWHAG YWHAZ	67 interacting genes: ALPP APC ARHGAP1 ATP5MC3 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 CAPN2 CDK5R2 CXCR1 DPYSL2 EGFR ENO2 EPB41 ETV6 FYN GNAI2 GPHN GRM7 HDAC6 HPCA HSPH1 IL1RL1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD NUPR1 OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 SKP1 SLC11A1 STARD13 STK16 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UBC UCHL5 VAV1 VDAC1 WNT6 YWHAG ZAP70
Entrez ID		375484	7277
HPRD ID		13486	01851
Ensembl ID		ENSG00000170085	ENSG00000127824
Uniprot IDs		B4DRM7 Q8NDZ2	P68366
PDB IDs		7T5P
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Protein Domain Specific Binding Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Hippocampal Mossy Fiber To CA3 Synapse Protein Sequestering Activity Cellular Response To Glucose Starvation Phosphorylation Protein Phosphorylation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Stability Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TOR Signaling Protein Kinase Binding Negative Regulation Of TOR Signaling PML Body Synaptonemal Complex Disassembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Golgi Inheritance Regulation Of TORC1 Signaling Synaptic Target Recognition Positive Regulation Of Proteasomal Protein Catabolic Process Golgi Organization Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Kinase C Inhibitor Activity Mitotic Cell Cycle Regulation Of TOR Signaling Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Nucleus Release From Viral Latency Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Protein Modification By Small Protein Conjugation Golgi Reassembly Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Cellular Response To Starvation Vesicle Phosphoserine Residue Binding Macromolecule Metabolic Process Positive Regulation Of Proteolysis	Alpha-tubulin Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Microtubule Cytosol Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Plasma Membrane Tubulin Binding Regulation Of Protein Catabolic Process Dendrite Positive Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Organelle Organization Cytoskeleton Regulation Of Multicellular Organismal Process Microtubule Binding Tau Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction Cell Motility Negative Regulation Of Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Bounded Cell Projection Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Leukocyte Migration Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To L-glutamate Inclusion Body Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Tubulin Complex Assembly
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