NCR3LG1 and TMEM14C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NCR3LG1	TMEM14C
Description		natural killer cell cytotoxicity receptor 3 ligand 1	transmembrane protein 14C
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Receptor Ligand Activity	Protein Binding Transmembrane Transporter Activity
	Biological Process	Signal Transduction NK T Cell Activation	Heme Biosynthetic Process Mitochondrial Transport Erythrocyte Differentiation Transmembrane Transport Regulation Of Heme Biosynthetic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Circulating leptin levels or type 2 diabetes ( 32341051)	Itch intensity from mosquito bite adjusted by bite size ( 28199695) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)
Interacting Genes		9 interacting genes: C14orf180 C3orf52 COL4A5 ERG28 PLPP6 STX8 TMEM14C TMEM222 TSPO	51 interacting genes: AQP6 ARL13B BCL2L13 BIK CLDN5 COMT COQ9 CPLANE2 CREB3 CREB3L1 CYB5R3 EBP ELOVL7 FAM209A GJB1 GORAB GPR152 GPX8 HSD17B13 KASH5 LMNA LNX1 MARCHF8 MFF MMGT1 MTERF3 MUC1 NCAPH2 NCR3LG1 PDZK1IP1 PLIN3 RCHY1 SAR1A SDC3 SHANK3 SLC10A6 SLC18A1 SLC35H1 SSMEM1 STX1A SYT1 TMEM14B TMEM31 TMEM35A TMEM52B TMEM79 TMEM86B TMX2 VSIR ZDHHC15 ZFYVE27
Entrez ID		374383	51522
HPRD ID		16820	15524
Ensembl ID		ENSG00000188211	ENSG00000111843
Uniprot IDs		Q68D85	Q9P0S9
PDB IDs		3PV6 3PV7 4ZSO 6YJP	2LOS
Enriched GO Terms of Interacting Partners?		Steroid Biosynthetic Process Tetrapyrrole Biosynthetic Process Heme Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Porphyrin-containing Compound Metabolic Process Steroid Metabolic Process Heme Metabolic Process Sterol Biosynthetic Process Tetrapyrrole Metabolic Process Pigment Metabolic Process Negative Regulation Of Corticosterone Secretion Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Contact Inhibition Response To Vitamin B1 Regulation Of Heme Biosynthetic Process Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Sterol Metabolic Process Negative Regulation Of Glucocorticoid Secretion Detection Of Cell Density Lipid Biosynthetic Process Androgen Binding Maintenance Of Protein Location In Mitochondrion Lipid Phosphatase Activity Regulation Of Corticosterone Secretion Collagen Type IV Trimer Farnesyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Peripheral Nervous System Axon Regeneration Membrane Chloride Channel Inhibitor Activity Lysophosphatidic Acid Phosphatase Activity Mitochondrial Membrane Positive Regulation Of Mitochondrial Depolarization Protein Prenylation C21-steroid Hormone Biosynthetic Process Cellular Hypotonic Response Benzodiazepine Receptor Activity Response To Acetylcholine Positive Regulation Of Programmed Necrotic Cell Death Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endoplasmic Reticulum Regulation Of Neutrophil Activation Hypotonic Response Negative Regulation Of Mitophagy	Membrane Endoplasmic Reticulum Membrane Identical Protein Binding Protein Binding Mitochondrial Membrane Endoplasmic Reticulum Clathrin-sculpted Monoamine Transport Vesicle Membrane Organelle Organization Norepinephrine Transport
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