EIF6 and SEPTIN3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF6	SEPTIN3
Description		eukaryotic translation initiation factor 6	septin 3
Image
GO Annotations	Cellular Component	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Intermediate Filament Synapse Extracellular Exosome	Cytoplasm Cytoskeleton Septin Ring Microtubule Cytoskeleton Septin Complex Cell Division Site Synapse Presynapse
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translation Translational Initiation Response To Insulin MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Ribosome Biogenesis Cytosolic Ribosome Assembly Ribosomal Large Subunit Biogenesis Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process	Intracellular Protein Localization Cell Division Cytoskeleton-dependent Cytokinesis
Pathways
Drugs		Copper
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26	26 interacting genes: CDC37 CENPM CHRM3 CKS1B CREBBP DDIT4L EIF6 GABARAPL2 LASP1 MAP1LC3B MAPK6 MOB1A NTAQ1 PELI2 PRKG1 RBX1 RNF4 RNF8 RSPH1 SDCBP SELENOF SEPTIN1 SLC25A17 SLC39A14 SNCA WBP2
Entrez ID		3692	55964
HPRD ID		04221	10515
Ensembl ID		ENSG00000242372	ENSG00000100167
Uniprot IDs		P56537	A0A2R8Y4H2 Q9UH03
PDB IDs		6LQM 6LSR 6LSS 6LU8 7OW7 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8OHD 8OJ0 8OJ8 8RL2 9GMO	3SOP 4Z51 4Z54 6UQQ
Enriched GO Terms of Interacting Partners?		Calyx Of Held Identical Protein Binding Regulation Of Proteolysis Regulation Of Translation Negative Regulation Of Gene Expression Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Viral Life Cycle Translation Anaphase-promoting Complex Binding Negative Regulation Of Cell Size Regulation Of Vesicle-mediated Transport Positive Regulation Of Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Viral Process Mitotic Nuclear Membrane Disassembly Centriolar Satellite Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Protein Binding Post-transcriptional Regulation Of Gene Expression Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Chemokine Production G Protein-coupled Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Receptor Internalization Negative Regulation Of Viral Process Double-stranded RNA Binding Membrane Disassembly Spindle Organization Nuclear Membrane Disassembly Endoplasmic Reticulum Unfolded Protein Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Endocytosis Antiviral Innate Immune Response Postsynaptic Density Organization Negative Regulation Of Translation Protein Disulfide Isomerase Activity Ribosome	Cytoplasm Cytosol Mitophagy Cellular Response To Nitrogen Starvation Regulation Of Phosphorus Metabolic Process Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Meiotic Spindle Ubiquitin-ubiquitin Ligase Activity Protein Modification Process Regulation Of Glutamate Secretion Sperm DNA Condensation Autophagosome Assembly Autophagosome Organization Cellular Response To Nutrient Levels Protein K48-linked Ubiquitination Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Secretion By Cell Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Ketone Metabolic Process Protein K6-linked Ubiquitination Protein Polyubiquitination Interleukin-5 Receptor Complex Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Protein Catabolic Process Phospholipid Binding Ubiquitin Protein Ligase Binding FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Monoatomic Anion:monoatomic Cation Symporter Activity Protein-N-terminal Glutamine Amidohydrolase Activity
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