IRAK2 and PELI2

Number of citations of the paper that reports this interaction (PubMedID 17675297)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		IRAK2	PELI2
Description		interleukin 1 receptor associated kinase 2	pellino E3 ubiquitin protein ligase family member 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane	Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Signaling Adaptor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Molecular Adaptor Activity	Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction Toll Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane	Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Sum eosinophil basophil counts ( 27863252)	Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		20 interacting genes: ARAF HRAS IL1R1 IRAK1 IRAK3 MYD88 PELI1 PELI2 PELI3 SARM1 SMAD2 SMURF1 STT3A TARDBP TICAM2 TIRAP TLR4 TOLLIP TRAF6 ZC3H12A	45 interacting genes: BCL10 CEP170B CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 IRS1 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MPDZ MYD88 MYO10 NEK9 NUP62 OR7D2 PCGF2 PICALM PRR36 RABEP1 RBBP8 REL RMDN3 RNF220 SEPTIN3 SP4 SRPK1 TGM2 THAP7 TIMM9 TMEM79 TP53 TP63 TRIM32 UBQLN4 YTHDF2
Entrez ID		3656	57161
HPRD ID		04491	17835
Ensembl ID		ENSG00000134070	ENSG00000139946
Uniprot IDs		O43187	Q9H716 Q9HAT8
PDB IDs		3MOP	3EGA 3EGB
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Immune Response Response To Lipopolysaccharide Cell Surface Pattern Recognition Receptor Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of Gene Expression Positive Regulation Of Cytokine Production Regulation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Response To External Biotic Stimulus Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cell Communication Immune Response-regulating Signaling Pathway Positive Regulation Of Signaling Regulation Of Defense Response Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Other Organism Activation Of Immune Response Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Innate Immune Response Lipopolysaccharide-mediated Signaling Pathway Immune System Process Positive Regulation Of Metabolic Process Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Defense Response To Other Organism Defense Response Response To Lipid Regulation Of Type I Interferon Production Innate Immune Response	Toll Signaling Pathway Non-canonical NF-kappaB Signal Transduction Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Interleukin-33-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process General Transcription Initiation Factor Binding Positive Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response-activating Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Activation Of Innate Immune Response Positive Regulation Of Defense Response Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Endolysosomal Toll-like Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Adaptor Activity Anatomical Structure Morphogenesis Regulation Of Apoptotic Signaling Pathway Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Defense Response Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Response To Stress Regulation Of Cell Communication Cellular Developmental Process Regulation Of Signaling Regulation Of Gene Expression Positive Regulation Of DNA-binding Transcription Factor Activity
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