AQP4 and AP3M1

Number of citations of the paper that reports this interaction (PubMedID 11742978)
52

Data Source:
HPRD (in vitro)

		AQP4	AP3M1
Description		aquaporin 4	adaptor related protein complex 3 subunit mu 1
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Sarcolemma Cell Projection Astrocyte End-foot	Cytoplasm Lysosome Lysosomal Membrane Early Endosome Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Postsynaptic Recycling Endosome Axon Cytoplasm
	Molecular Function	Protein Binding Water Channel Activity Channel Activity Identical Protein Binding	Protein Binding Small GTPase Binding
	Biological Process	Renal Water Homeostasis Water Transport Intracellular Water Homeostasis Multicellular Organismal-level Water Homeostasis Protein Homotetramerization Transmembrane Transport Cellular Response To Type II Interferon Cerebrospinal Fluid Circulation	Protein Targeting To Lysosome Intracellular Protein Transport Endocytosis Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Postsynaptic Neurotransmitter Receptor Internalization Melanosome Assembly
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate ( 29403010) Metabolite levels ( 23823483)	Cardiac troponin-I levels ( 31014085) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: AP2M1 AP3M1 CREB3 CSNK2A1 CSNK2A2 GJA8 HPCAL4	14 interacting genes: AGTRAP AQP4 ARNT2 CRMP1 DVL3 IL36RN RUFY1 SIPA1L2 SLC12A4 SPAG16 TGOLN2 TRIM14 TRIM23 TRIM9
Entrez ID		361	26985
HPRD ID		02631	16496
Ensembl ID		ENSG00000171885	ENSG00000185009
Uniprot IDs		A0A5F9ZHR4 F1DSG4 P55087 V9PBN7	B4DRN6 Q9Y2T2
PDB IDs		3GD8 8V8S 8V91 8V9D	9C58 9C59 9C5A 9C5B 9C5C
Enriched GO Terms of Interacting Partners?		Protein Kinase CK2 Complex Postsynaptic Neurotransmitter Receptor Internalization Clathrin Adaptor Complex PcG Protein Complex Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Receptor Internalization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Separation Positive Regulation Of Deacetylase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Vesicle-mediated Transport In Synapse Protein Localization To Vacuole Intracellular Protein Transport Negative Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Signal Sequence Binding Receptor-mediated Endocytosis Extrinsic Component Of Presynaptic Endocytic Zone Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Positive Regulation Of Aggrephagy Release From Viral Latency Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Gap Junction-mediated Intercellular Transport CCR1 Chemokine Receptor Binding Postsynaptic Recycling Endosome Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Double-strand Break Repair Negative Regulation Of Apoptotic Process Intercellular Transport CAMP Response Element Binding Protein Binding AP-2 Adaptor Complex Double-strand Break Repair Via Classical Nonhomologous End Joining Negative Regulation Of Programmed Cell Death AP-3 Adaptor Complex Wnt Signaling Pathway Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA	Cerebrospinal Fluid Circulation
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