ILF2 and EXOSC8

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		ILF2	EXOSC8
Description		interleukin enhancer binding factor 2	exosome component 8
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Specific Granule Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding	RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding
	Biological Process	Positive Regulation Of DNA-templated Transcription	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		Neutrophil degranulation PKR-mediated signaling	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS
Interacting Genes		23 interacting genes: CCNDBP1 CEBPA DYNLT1 EEF1G EIF2AK2 EP300 ERG EXOSC8 H19 IL7R INCA1 IQGAP1 KCNN3 KRTAP6-3 MEOX2 OGT PICK1 PRKDC PTEN SGSM2 SREK1 TRIM27 ZMYND12	118 interacting genes: AEN ANKHD1 ATF2 C22orf39 CAB39L CCDC28A-AS1 CCL14 CCSER2 CNNM3 COL23A1 COX5A CPSF7 CRMP1 CWC22 DDIT4L DIS3 DUSP23 EEF1DP3 ERAL1 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 FSAF1 FYTTD1 GEM HAPLN2 HOXB9 ILF2 INCA1 KANK2 KCNJ11 LENG1 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR MAPK8IP1 METTL14 MKRN1 MORN4 MRPL2 MTREX MYOZ1 N4BP2L2 NEDD9 NTAQ1 NXF1 OTUD4 PACSIN2 PALS2 PDCD1LG2 PHF21A PIAS2 PKP2 POLDIP3 PRC1 PRPF31 PRPF6 PRR3 RASD1 RASSF1 RBBP4 RBM22 RBM7 REL RERG RFC5 RPL3 RPLP0 RPP14 RPS28 RUSC1 RXRB SARNP SF1 SFPQ SGO2 SLAIN1 SLIRP SNAI1 SNRPA SNRPB SNRPC SNRPN SNW1 SOCS7 SPATC1L SRPK2 SRSF10 SUGP2 TBRG1 TCEA2 TFAP4 TFIP11 TXNDC17 TXNDC9 UBC UNKL UPF2 USP2 USP6 UTP14A XRN1 XRN2 ZFP36
Entrez ID		3608	11340
HPRD ID		04419	09351
Ensembl ID		ENSG00000143621	ENSG00000120699
Uniprot IDs		B4DY09 F4ZW62 Q12905 Q53FG3	Q96B26
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		STAT Family Protein Binding Regulation Of Phosphorus Metabolic Process Negative Regulation Of Phosphate Metabolic Process Protein Domain Specific Binding Chromatin DNA Binding Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Biosynthetic Process Leukocyte Differentiation Nucleoplasm Defense Response Positive Regulation Of RNA Biosynthetic Process Response To Nutrient Levels Positive Regulation Of Gene Expression Regulation Of Cell Development Negative Regulation Of Cell Cycle Cell Development Mononuclear Cell Differentiation Positive Regulation Of DNA-templated Transcription RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Cytoplasm Protein Modification Process T Cell Lineage Commitment Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Peptidyl-lysine Propionylation Histone Acetyltransferase Complex Protein-DNA Complex Regulation Of Protein Modification Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Lymphocyte Differentiation Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Cellular Response To Nutrient Levels Circadian Rhythm Histone Crotonyltransferase Activity Rhythmic Process Phosphorylation Protein Phosphorylation T Cell Differentiation In Thymus Neuron Projection Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Phosphorylation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Phosphorylation	RNA Binding MRNA Metabolic Process Exosome (RNase Complex) RNA Processing RNA Metabolic Process Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleic Acid Metabolic Process Nucleolar Exosome (RNase Complex) RNA Splicing, Via Transesterification Reactions Nucleus Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance RNA Catabolic Process MRNA Splicing, Via Spliceosome MRNA Catabolic Process RNA Exonuclease Activity MRNA Processing RNA Splicing Nucleoplasm Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Nuclear RNA Surveillance U4 SnRNA 3'-end Processing RNA Surveillance RRNA Catabolic Process 3'-5'-RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nucleic Acid Binding SnRNA Metabolic Process RRNA Metabolic Process RRNA Processing Catalytic Step 2 Spliceosome Poly(A)-dependent SnoRNA 3'-end Processing SnRNA 3'-end Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process Nucleolus Exoribonuclease Complex Negative Regulation Of Macromolecule Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process SnRNA Processing RNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding
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