IL3RA and TMEM128

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL3RA	TMEM128
Description		interleukin 3 receptor subunit alpha	transmembrane protein 128
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Membrane
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding	Protein Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Sargramostim Tagraxofusp
Diseases
GWAS		Schizophrenia ( 17522711)	Glomerular filtration rate ( 24351856)
Interacting Genes		32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5	66 interacting genes: AQP6 ARL13B BCL2L13 BEST2 CD40 CD53 CD79A CLDN5 CLDN7 CLN8 CPLX4 CREB3L1 CYB561 CYBC1 ELOVL4 ERGIC3 FAM209A FFAR2 GAD2 GJA1 GJA8 GJB5 GORAB GPR152 GPR42 GPX8 HSD17B11 HSD17B13 IER3IP1 IL3RA JAGN1 KCNK5 LEUTX LHFPL2 LHFPL5 LMNA MAPK8IP2 MFF MRPS18B MTERF1 MTIF3 MUC1 REEP4 RETREG3 SCN3B SEC11C SHISAL1 SLC10A6 SLC18A1 SLC1A3 SLC26A6 SLC34A2 SLC35H1 SLC61A1 SLC7A14 SSMEM1 STX1A TMEM106A TMEM237 TMEM45B TMEM52B TMEM80 TMPRSS2 TMX2 ZDHHC15 ZFYVE27
Entrez ID		3563	85013
HPRD ID		02392	17483
Ensembl ID		ENSG00000185291	ENSG00000132406
Uniprot IDs		P26951	B7Z3K1 Q5BJH2
PDB IDs		4JZJ 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?		Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Positive Regulation Of Establishment Of Protein Localization Regulation Of Organ Growth Regulation Of Peptide Hormone Secretion Regulation Of Establishment Of Protein Localization Interleukin-5-mediated Signaling Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Cellular Response To Interleukin-3 Positive Regulation Of Protein Transport Neutrophil Differentiation Positive Regulation Of Organ Growth Regulation Of Cell Population Proliferation Regulation Of Protein Transport Ventricular Cardiac Muscle Cell Development Positive Regulation Of Protein Localization Growth Hormone Receptor Binding Regulation Of Hormone Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Regulation Of Protein Secretion Establishment Of Protein Localization To Plasma Membrane Mitotic Nuclear Membrane Disassembly Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Heart Growth Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Nuclear Membrane Disassembly Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Disassembly Interleukin-6-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Establishment Of Protein Localization To Membrane Regulation Of Growth Positive Regulation Of Protein Localization To Nucleus Nuclear Envelope Organization Growth Hormone Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Circadian Rhythm Positive Regulation Of Cardiac Muscle Cell Proliferation Myeloid Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Membrane Protein Binding Endoplasmic Reticulum Organization Endoplasmic Reticulum Transmembrane Transport Inorganic Anion Transport Acidic Amino Acid Transport Neurotransmitter Transport Endoplasmic Reticulum Membrane Connexin Complex Steroid Dehydrogenase Activity Organic Anion Transport Gap Junction Channel Activity Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Plasma Membrane Gap Junction Monoatomic Ion Transport Dicarboxylic Acid Transport Neurotransmitter Uptake Gamma-aminobutyric Acid Biosynthetic Process Gamma-aminobutyric Acid Metabolic Process Carboxylic Acid Transport Organic Acid Transport Atrial Cardiac Muscle Cell Action Potential Chloride Transmembrane Transport Chloride Transport L-glutamate Import Across Plasma Membrane Efflux Transmembrane Transporter Activity
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