IHH and RHOD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IHH	RHOD
Description		Indian hedgehog signaling molecule	ras homolog family member D
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Extracellular Matrix	Golgi Membrane Mitochondrial Outer Membrane Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cell Projection
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Transferase Activity Hydrolase Activity Very-low-density Lipoprotein Particle Binding Metal Ion Binding Cholesterol-protein Transferase Activity	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Skeletal System Development Ossification Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Morphogenesis Of A Branching Structure Vasculature Development Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Proteoglycan Metabolic Process Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Pattern Specification Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Embryonic Pattern Specification Regulation Of Gene Expression Intein-mediated Protein Splicing Protein Autoprocessing Vitelline Membrane Formation Pancreas Development Negative Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Chondrocyte Proliferation Regulation Of Growth Embryonic Digit Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Eye Pigmentation Cell Maturation Embryonic Digestive Tract Morphogenesis Embryonic Camera-type Eye Morphogenesis Neuron Development System Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Maternal Process Involved In Female Pregnancy Camera-type Eye Photoreceptor Cell Fate Commitment Head Morphogenesis Somite Development Embryonic Skeletal Joint Development Epithelial Cell-cell Adhesion Self Proteolysis Liver Regeneration	Protein Targeting Actin Filament Organization Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Projection Assembly Lamellipodium Assembly Actin Filament Polymerization Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Focal Adhesion Assembly Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Focal Adhesion Assembly Response To Fibroblast Growth Factor
Pathways		Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np RUNX2 regulates chondrocyte maturation Formation of lateral plate mesoderm	RHO GTPases Activate Formins RHOD GTPase cycle
Drugs
Diseases		Acrocapitofemoral dysplasia Brachydactyly, including: type A; type B; type D; type E
GWAS		Height ( 18391951 18391952 20189936 20881960 31562340) Waist circumference adjusted for body mass index ( 26785701)	Height ( 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: HHIP PTCH1 PTCH2 RHOD	13 interacting genes: ACVR1 ADCK5 ADRB2 ANKFY1 BMPR1B DIAPH2 HRAS IHH PLXNA1 SMAD2 SMAD4 SMURF2 TGFBR1
Entrez ID		3549	29984
HPRD ID		02839	05776
Ensembl ID		ENSG00000163501	ENSG00000173156
Uniprot IDs		Q14623	E9PIG5 O00212
PDB IDs		3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P	2J1L 7KDC
Enriched GO Terms of Interacting Partners?		Hedgehog Family Protein Binding Negative Regulation Of Smoothened Signaling Pathway Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Regulation Of Smoothened Signaling Pathway Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Cell Fate Determination Ciliary Membrane Positive Regulation Of Epithelial Cell Differentiation Regulation Of Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Regulation Of Epidermis Development Cell Fate Specification Neural Plate Axis Specification Branching Morphogenesis Of An Epithelial Tube Epidermis Development Response To Chlorate Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Epithelial Cell Differentiation Regulation Of Signal Transduction Tube Morphogenesis Regulation Of Cell Communication Patched Binding Cell Proliferation Involved In Metanephros Development Mammary Gland Duct Morphogenesis Neural Tube Patterning Dendritic Growth Cone Regulation Of Signaling Regionalization Negative Regulation Of Signal Transduction Neural Tube Formation Metanephric Collecting Duct Development Morphogenesis Of An Epithelium Cell Proliferation Involved In Kidney Development Negative Regulation Of Cell Communication Negative Regulation Of Signaling Pattern Specification Process Negative Regulation Of Multicellular Organism Growth Commissural Neuron Axon Guidance Tissue Morphogenesis Collecting Duct Development Dorsal/ventral Neural Tube Patterning Hair Cycle Negative Regulation Of Cell Division Somite Development Prostate Gland Development Cellular Response To Cholesterol	SMAD Binding Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Pattern Specification Process Positive Regulation Of Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Morphogenesis I-SMAD Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling In Utero Embryonic Development Chordate Embryonic Development Transforming Growth Factor Beta Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Developmental Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Animal Organ Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Cellular Response To BMP Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Responsive Factor Complex Regulation Of Ossification Osteoblast Differentiation Ameboidal-type Cell Migration Anatomical Structure Morphogenesis Response To Growth Factor Neuron Fate Commitment Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Enzyme-linked Receptor Protein Signaling Pathway Developmental Growth Gastrulation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biomineral Tissue Development Tissue Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Ossification Mesoderm Development Embryonic Morphogenesis Activin Receptor Complex
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