CCN1 and SFTPD

		CCN1	SFTPD
Description		cellular communication network factor 1	surfactant protein D
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Collagen Trimer Extracellular Space Cytoplasm Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Growth Factor Binding Extracellular Matrix Binding	Protein Binding Carbohydrate Binding Identical Protein Binding
	Biological Process	Osteoblast Differentiation Intussusceptive Angiogenesis Atrioventricular Valve Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Ventricular Septum Development Apoptotic Process Chemotaxis Cell Adhesion Signal Transduction Integrin-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Atrial Septum Morphogenesis Chondroblast Differentiation Chorio-allantoic Fusion Labyrinthine Layer Blood Vessel Development Positive Regulation Of Cartilage Development Regulation Of ERK1 And ERK2 Cascade Reactive Oxygen Species Metabolic Process Cell-cell Adhesion Regulation Of Multicellular Organismal Development Positive Regulation Of Ceramide Biosynthetic Process	Regulation Of Cytokine Production Immune System Process Regulation Of Immune System Process Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Reactive Oxygen Species Metabolic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs			Beta-D-Glucose
Diseases
GWAS		Appendicular lean mass ( 33097823)	Chronic obstructive pulmonary disease ( 28166215 30804561 33909500) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Lung function (FEV1/FVC) ( 30804560) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		9 interacting genes: ANXA1 CDC42 DYRK1A ITGAV ITGB5 NEIL3 SFTPD SMPD2 UBQLN2	12 interacting genes: CCN1 DCN DMBT1 GPA33 KCNMA1 LBR MFAP4 PLAU PLXNA3 RBX1 SFTPA1 SMR3B
Entrez ID		3491	6441
HPRD ID		09089	01522
Ensembl ID		ENSG00000142871	ENSG00000133661
Uniprot IDs		O00622 Q6FI18	P35247
PDB IDs		4D0Z 4D11	1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS
Enriched GO Terms of Interacting Partners?		Integrin Alphav-beta5 Complex Regulation Of Vesicle-mediated Transport Phagocytic Vesicle Regulation Of Endocytosis Integrin-mediated Signaling Pathway Mononuclear Cell Migration Wound Healing, Spreading Of Epidermal Cells Focal Adhesion Cell Migration Endocytosis Apoptotic Cell Clearance Cell Motility Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Endodermal Cell Differentiation Import Into Cell Leukocyte Migration Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Chemotaxis Regulation Of Interleukin-2 Production Histone H3T45 Kinase Activity Entry Into Host Cell By A Symbiont-containing Vacuole Formation Of Primary Germ Layer Opsonin Binding MCM Complex Binding Regulation Of Transport Locomotion Actin Cytoskeleton Organization Signaling Receptor Binding Actin Filament-based Process Phagocytosis Actin Filament GBD Domain Binding Storage Vacuole Integrin Alphav-beta3 Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Virus Receptor Activity Integrin Alphav-beta8 Complex Negative Regulation Of G Protein-coupled Receptor Internalization Cell Periphery Negative Regulation Of Transport Regulation Of Phagocytosis Cell-matrix Adhesion Endothelin Receptor Signaling Pathway Involved In Heart Process Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex	Extracellular Space Extracellular Matrix Extracellular Region Extracellular Matrix Binding
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