IFI16 and ID1

Number of citations of the paper that reports this interaction (PubMedID 11940648)
76

Data Source:
HPRD (in vivo, in vitro)

		IFI16	ID1
Description		interferon gamma inducible protein 16	inhibitor of DNA binding 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Transcription Factor Binding Identical Protein Binding	Transcription Corepressor Activity Protein Binding Protein Dimerization Activity Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Immune System Process Autophagy Apoptotic Process Inflammatory Response Regulation Of Autophagy Myeloid Cell Differentiation Monocyte Differentiation Positive Regulation Of Interleukin-1 Beta Production Cellular Response To Interferon-beta Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Binding Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Defense Response To Virus Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of AIM2 Inflammasome Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Endothelial Cell Morphogenesis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Circadian Rhythm Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Neuron Differentiation BMP Signaling Pathway Protein Destabilization Collagen Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of DNA-binding Transcription Factor Activity Blood Vessel Endothelial Cell Migration Negative Regulation Of Osteoblast Differentiation Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Response To Antibiotic Rhythmic Process Blood Vessel Morphogenesis Lung Morphogenesis Lung Vasculature Development Endothelial Cell Apoptotic Process Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		STING mediated induction of host immune responses IRF3-mediated induction of type I IFN	Oncogene Induced Senescence NGF-stimulated transcription Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		C-reactive protein ( 22939635) Celiac disease or Rheumatoid arthritis ( 21383967) Lymphocyte percentage of white cells ( 32888494) Neutrophil count in HIV-infection ( 25884002) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Periodontal disease-related phenotype (Socransky) ( 26962152)	Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		13 interacting genes: APP AR AURKA BRCA1 CEBPA CSNK2A1 ID1 ID2 ID3 STING1 TP53 TP53BP1 TPR	29 interacting genes: AAR2 APPL1 ASCL3 ASXL1 CASK COPB1 DNMT3L ELK1 ELK4 GATA4 HES1 IFI16 IKBKG MSGN1 MYF5 MYF6 MYOD1 MYOG POFUT1 PSMD4 RNF4 RUNX1T1 SUV39H1 TCF12 TCF3 TCF4 TRIM55 TRIM63 UBC
Entrez ID		3428	3397
HPRD ID		00969	08980
Ensembl ID		ENSG00000163565	ENSG00000125968
Uniprot IDs		Q16666	P41134
PDB IDs		2OQ0 3B6Y 3RLN 3RLO 3RNU 4QGU 8X70
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Developmental Process Intracellular Signal Transduction DNA Damage Checkpoint Signaling Molecular Function Activator Activity Rhythmic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Positive Regulation Of Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Circadian Rhythm Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Transcription Regulator Inhibitor Activity Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation	Positive Regulation Of Transcription By RNA Polymerase II E-box Binding Protein Dimerization Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Macromolecule Metabolic Process DNA Binding Chromatin Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Muscle Cell Fate Commitment Positive Regulation Of Metabolic Process Cell Fate Commitment Sequence-specific Double-stranded DNA Binding Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Striated Muscle Tissue Development Regulation Of Gene Expression DNA-binding Transcription Factor Activity RNA Polymerase II Transcription Regulator Complex Regulation Of Skeletal Muscle Tissue Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Anterior/posterior Pattern Specification Regulation Of Striated Muscle Tissue Development Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Regulation Of Myotube Differentiation Positive Regulation Of Myoblast Differentiation Regulation Of Metabolic Process Somitogenesis Animal Organ Development Cell Differentiation Regulation Of Macromolecule Metabolic Process Tissue Regeneration Segmentation Muscle Organ Development
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