IDI1 and PITRM1

		IDI1	PITRM1
Description		isopentenyl-diphosphate delta isomerase 1	pitrilysin metallopeptidase 1
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GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol	Mitochondrion Mitochondrial Matrix
	Molecular Function	Magnesium Ion Binding Isopentenyl-diphosphate Delta-isomerase Activity Protein Binding Isomerase Activity Intramolecular Oxidoreductase Activity Manganese Ion Binding Metal Ion Binding	Metalloendopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process Sterol Biosynthetic Process Response To Stilbenoid Dimethylallyl Diphosphate Biosynthetic Process	Proteolysis Protein Targeting To Mitochondrion Protein Processing
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Mitochondrial protein import
Drugs		Dimethylallyl Diphosphate
Diseases
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Metabolite levels ( 23823483) Scalp hair shape ( 26926045)
Interacting Genes		7 interacting genes: BARD1 BCL2L13 LARP4B PITRM1 TXNIP WT1 ZNF655	9 interacting genes: BID DPT IDI1 LARP4B MFN2 PNLIPRP1 S100A7 SOCS6 WDR77
Entrez ID		3422	10531
HPRD ID		07235	07142
Ensembl ID		ENSG00000067064	ENSG00000107959
Uniprot IDs		A0A8Q3WKR8 Q13907	A0A0A0MRX9 A0A7I2V397 Q5JRX3
PDB IDs		2DHO 2I6K 2ICJ 2ICK	4L3T 4NGE 4RPU 6XOS 6XOT 6XOU 6XOV 6XOW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death BRCA1-B Complex Regulation Of Programmed Cell Death Histone H2AK127 Ubiquitin Ligase Activity Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex Hemi-methylated DNA-binding Negative Regulation Of Female Gonad Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Metanephric S-shaped Body Morphogenesis Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Cellular Response To Tumor Cell BRCA1-A Complex Nuclear Ubiquitin Ligase Complex Negative Regulation Of Protein Export From Nucleus BRCA1-C Complex Negative Regulation Of Mitotic Cell Cycle Phase Transition Ubiquitin-modified Histone Reader Activity Negative Regulation Of Mitotic Cell Cycle Diaphragm Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Female Gonad Development Thorax And Anterior Abdomen Determination Positive Regulation Of Male Gonad Development S-shaped Body Morphogenesis Cardiac Muscle Cell Fate Commitment Double-stranded Methylated DNA Binding Metanephric Mesenchyme Development Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Negative Regulation Of Cell Cycle Phase Transition Regulation Of MRNA 3'-end Processing Zinc Ion Binding Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Process Nucleolus Nephron Tubule Morphogenesis Podocyte Differentiation Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process DNA Strand Resection Involved In Replication Fork Processing Metanephric Epithelium Development	Protein Targeting To Mitochondrion
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