ID4 and GRIN2A

		ID4	GRIN2A
Description		inhibitor of DNA binding 4	glutamate ionotropic receptor NMDA type subunit 2A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Synaptic Membrane Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Transcription Corepressor Activity Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Metal Ion Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Positive Regulation Of Neuroblast Proliferation Neuroblast Proliferation Brain Development Circadian Rhythm Intracellular Protein Localization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Hippocampus Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Differentiation Central Nervous System Myelination Neuron Differentiation Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Oligodendrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Prostate Gland Morphogenesis Prostate Gland Epithelium Morphogenesis Prostate Gland Stromal Morphogenesis Seminal Vesicle Morphogenesis	Startle Response Response To Amphetamine Monoatomic Ion Transport Calcium Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Learning Memory Visual Learning Response To Xenobiotic Stimulus Response To Wounding Sensory Perception Of Pain Calcium-mediated Signaling Neurogenesis Protein Catabolic Process Sleep Directional Locomotion Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Sodium Ion Transmembrane Transport Locomotion Negative Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Dopamine Metabolic Process Serotonin Metabolic Process Positive Regulation Of Apoptotic Process Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Amyloid-beta Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		NGF-stimulated transcription Formation of the nephric duct	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Felbamate Memantine Halothane Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Age at first birth ( 34211149) Age at voice drop ( 27182965) Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Chronotype ( 30696823) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Endometriosis ( 23472165 28333195 28537267) Free thyroxine concentration ( 30367059) Height ( 28552196 20881960) Hip circumference adjusted for BMI ( 34021172) Loneliness (multivariate analysis) ( 27629369) Response to statin therapy ( 20339536) Waist circumference adjusted for body mass index ( 34021172)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bevacizumab-induced composite toxicity (either hypertension or proteinuria) ( 34616010) Bipolar disorder ( 33263727 31043756 34002096) Bipolar I disorder ( 31043756) Chronic kidney disease ( 26420894) Clostridioides difficle infection ( 33841421) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Daytime nap ( 33568662) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Hallux valgus ( 32131869) Hepatitis B ( 22004137) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FVC) ( 30804560) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 29483656 28991256 25056061) Tenofovir clearance in HIV infection ( 26148204) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)
Interacting Genes		5 interacting genes: GRIN2A HES1 ID3 MYOD1 TCF4	40 interacting genes: ACOT8 ACTN1 AKT1 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CARHSP1 CASK CDK5 CSNK2A1 CSNK2A2 CSNK2B DLG1 DLG2 DLG3 DLG4 DLGAP1 EML1 FYN GRIN1 GRIN3A GRIN3B ID4 IL16 NEDD4 PATJ PCDH8 PLA2G10 PLCG1 PRKCA PRM1 PTK2B PTPN4 RGS3 RNF40 SPTAN1 SRC
Entrez ID		3400	2903
HPRD ID		08995	00698
Ensembl ID		ENSG00000172201	ENSG00000183454
Uniprot IDs		P47928	A0A890YTL4 Q12879 Q547U9 Q59EW6
PDB IDs			3NFL 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH 7EOQ 7EOR 7EOS 7EOT 7EOU 7EU7 8E99 8JIZ 8JJ0 8JJ1 8JJ2 8VUH 8VUJ 8VUL 8VUN 8VUQ 8VUR 8VUT
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity E-box Binding Cell Differentiation Cellular Response To Oxygen-containing Compound Cell Fate Determination Cellular Response To Fatty Acid BHLH Transcription Factor Binding Cellular Developmental Process Animal Organ Development Regulation Of Cell Differentiation Muscle Cell Development Negative Regulation Of Pancreatic A Cell Differentiation N-box Binding Negative Regulation Of Cell Fate Determination Positive Regulation Of Mitotic Cell Cycle, Embryonic Cellular Response To Lipid Trochlear Nerve Development Response To Fatty Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Leptomycin B Regulation Of Myoblast Differentiation Leptomycin B Binding Sequence-specific Double-stranded DNA Binding Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Oculomotor Nerve Development Cajal-Retzius Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation Response To Tumor Necrosis Factor Hindbrain Morphogenesis Renal Interstitial Fibroblast Development Muscle Organ Development Myoblast Fate Determination Directional Locomotion Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Ureteric Bud Morphogenesis Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Amacrine Cell Differentiation Embryonic Organ Development Negative Regulation Of Pro-B Cell Differentiation Cell Fate Commitment Regulation Of Mitotic Cell Cycle, Embryonic HLH Domain Binding Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis Stomach Neuroendocrine Cell Differentiation Response To Aroclor 1254 Regulation Of Forebrain Neuron Differentiation	Ionotropic Glutamate Receptor Binding Postsynaptic Density Regulation Of Metal Ion Transport Synapse Regulation Of Monoatomic Ion Transport Cytosol Cell Junction Modulation Of Chemical Synaptic Transmission Regulation Of Calcium Ion Transport Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Glutamatergic Synapse Regulation Of Transport NMDA Selective Glutamate Receptor Complex Calcium Ion Transport Trans-synaptic Signaling Postsynaptic Density Membrane Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Plasma Membrane Protein Kinase CK2 Complex Glycine-gated Cation Channel Activity Protein Kinase Activity Regulation Of Synaptic Plasticity Ligand-gated Ion Channel Signaling Pathway Regulation Of Membrane Potential Neuron Projection Metal Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Kinase Activity Receptor Clustering Regulation Of Protein Localization To Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Phosphate-containing Compound Metabolic Process Regulation Of Cellular Localization Regulation Of Biological Quality Protein Localization To Synapse Protein Serine/threonine Kinase Activity Regulation Of Protein Localization To Plasma Membrane Regulation Of Synapse Organization NMDA Glutamate Receptor Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Monoatomic Cation Transport Transmembrane Transporter Binding Cell-cell Signaling GMP Kinase Activity Protein Phosphorylation Regulation Of Signaling Neuromuscular Junction Regulation Of Cell Communication
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