TAFA2 and KIR3DL2

Number of citations of the paper that reports this interaction (PubMedID 36178190)
90

Data Source:
BioGRID (pull down)

		TAFA2	KIR3DL2
Description		TAFA chemokine like family member 2	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm	Plasma Membrane Membrane
	Molecular Function	Receptor Ligand Activity	Protein Binding MHC Class Ib Protein Binding
	Biological Process	Signal Transduction Memory Visual Learning	Immune Response-regulating Signaling Pathway Cellular Defense Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)	Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: KIR2DL5A KIR3DL1 KIR3DL2 KIR3DL3 RNF167	2 interacting genes: HLA-A TAFA2
Entrez ID		338811	3812
HPRD ID		16876	10384
Ensembl ID		ENSG00000198673	ENSG00000240403
Uniprot IDs		Q8N3H0	A0A0U1WNF3 A0A376A965 P43630 Q8NHI6 Q8NHK6
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Immune System Process HLA-B Specific Inhibitory MHC Class I Receptor Activity Plasma Membrane MHC Class Ib Protein Binding Cellular Response To Leucine Starvation Protein K29-linked Ubiquitination	Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Memory T Cell Activation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent TAP Binding T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target TAP Complex Binding CD8 Receptor Binding MHC Class I Protein Complex MHC Class I Peptide Loading Complex CD8-positive, Alpha-beta T Cell Activation Protection From Natural Killer Cell Mediated Cytotoxicity Beta-2-microglobulin Binding Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Immune Response To Tumor Cell Peptide Antigen Assembly With MHC Class I Protein Complex Golgi Medial Cisterna Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Detection Of Bacterium T Cell Receptor Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib T Cell Mediated Cytotoxicity Regulation Of CD8-positive, Alpha-beta T Cell Activation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of T Cell Cytokine Production Lumenal Side Of Endoplasmic Reticulum Membrane Detection Of Biotic Stimulus Antigen Processing And Presentation Of Endogenous Antigen Endoplasmic Reticulum Exit Site Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Mediated Immunity Peptide Antigen Binding Regulation Of T Cell Cytokine Production Antigen Processing And Presentation Of Exogenous Peptide Antigen Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Antigen Regulation Of Natural Killer Cell Mediated Cytotoxicity Visual Learning ER To Golgi Transport Vesicle Membrane Regulation Of Natural Killer Cell Mediated Immunity Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Antibacterial Humoral Response Extracellular Space Visual Behavior Positive Regulation Of Cell Killing
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