APOB and CALR

Number of citations of the paper that reports this interaction (PubMedID 10513896)
0

Data Source:
HPRD (in vitro, in vivo)

		APOB	CALR
Description		apolipoprotein B	calreticulin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Neuronal Cell Body Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Endocytic Vesicle Lumen	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion External Side Of Plasma Membrane Cell Surface Endomembrane System Membrane Sarcoplasmic Reticulum Phagocytic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Cytolytic Granule Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm Cortical Granule Extracellular Exosome Endocytic Vesicle Lumen Lumenal Side Of Endoplasmic Reticulum Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipase Binding Receptor Ligand Activity Low-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity	Complement Component C1q Complex Binding DNA Binding RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Folding Chaperone Metal Ion Binding Nuclear Androgen Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding Molecular Sequestering Activity
	Biological Process	In Utero Embryonic Development Lipid Metabolic Process Triglyceride Mobilization Lipid Transport Signal Transduction Spermatogenesis Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process Fertilization Response To Virus Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Lipid Catabolic Process Triglyceride Catabolic Process Cholesterol Transport Flagellated Sperm Motility Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Establishment Of Localization In Cell Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta	Negative Regulation Of Transcription By RNA Polymerase II Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of DNA-templated Transcription Protein Folding Protein Export From Nucleus Intracellular Calcium Ion Homeostasis Spermatogenesis Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Translation Cortical Actin Cytoskeleton Organization Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Protein Folding In Endoplasmic Reticulum ERAD Pathway Regulation Of Meiotic Nuclear Division Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Protein Maturation Cardiac Muscle Cell Differentiation Cellular Response To Electrical Stimulus Cellular Response To Lithium Ion Cellular Senescence Cellular Response To Virus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Trophoblast Cell Migration Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Peptide Response To Glycoside Response To Biphenyl Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance LDL clearance LDL clearance LDL remodeling VLDL clearance VLDL clearance Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport	ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Zinc chloride Zinc sulfate, unspecified form	Antihemophilic factor, human recombinant Tenecteplase Melatonin Lanoteplase Copper Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate
Diseases		Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586) Binge eating behaviour and bipolar disorder ( 24882193) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 30510157) Cholesterol, total ( 19060911 20686565 24097068 25961943 26582766) Coronary artery disease ( 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Erectile dysfunction and prostate cancer treatment ( 20932654) Gastroesophageal reflux disease ( 31527586) HDL cholesterol ( 19060911 20686565 20864672 25961943 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18193043 18193044 18262040 19060906 19060910 19060911 20686565 20864672 21059979 21347282 23726366 24097068 24507774 25961943 26582766 26780889 30275531) LDL cholesterol levels ( 17463246 26690388 28334899 30698716 31087446 32203549 32759990) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipid or lipoprotein levels ( 23696881) Lipoprotein (a) levels ( 33730874) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 31589552) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Non-HDL cholesterol levels ( 32902719) Oxidized LDL cholesterol levels ( 31150472) Pancreatic cancer ( 30206226) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30224653) Red cell distribution width ( 32888494) Response to statin therapy ( 20339536) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 26690388 28334899 30275531 30718733 31087446 32902719 33339817) Triglyceride levels ( 29403010 32154731 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 18193044 19060906 19060911 20686565 20864672 25961943 26160806)	Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Platelet count ( 32888494) Red blood cell traits ( 23222517)
Interacting Genes		25 interacting genes: AKT2 APOA1 ARFGAP1 BGN CALR CANX CD36 HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MDM2 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3 TREM2	53 interacting genes: APOB APP AR B2M CD1D F5 F8 FBN1 FGB GSC2 HLA-C HLA-E ICAM1 ICAM3 ITGA2B ITGA3 ITGAV ITIH1 LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 OGT PDE4B PDIA2 PDIA3 PLAT PLP1 PRF1 PTPN11 RNY1 RNY3 RNY4 SCARF1 SGTB SIRPA SLC2A1 SLC6A4 SMARCB1 SQSTM1 SUMO4 TAF1B TAPBP TF THBS1 TSHR UBE3A UPF2 VWF
Entrez ID		338	811
HPRD ID		00133	00169
Ensembl ID		ENSG00000084674	ENSG00000179218
Uniprot IDs		A0AAG2UUW0 P04114 Q59HB3 Q7Z7Q0	P27797 V9HW88
PDB IDs		9BD1 9BD8 9BDE 9BDT 9COO 9E9R 9EA7 9EAG	2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY 7QPD 8TZO 8TZR
Enriched GO Terms of Interacting Partners?		Unfolded Protein Binding Protein Folding Intracellular Protein Localization Endoplasmic Reticulum Lumen Lipoprotein Particle Binding Protein Folding Chaperone Establishment Of Protein Localization Protein Transport Regulation Of Protein Stability ATP-dependent Protein Folding Chaperone Protein Folding In Endoplasmic Reticulum Low-density Lipoprotein Particle Receptor Activity Catabolic Process Melanosome Protein Catabolic Process Low-density Lipoprotein Particle Binding Endocytic Vesicle Lumen Response To Endoplasmic Reticulum Stress Protein Stabilization Amyloid-beta Metabolic Process Endoplasmic Reticulum Amyloid-beta Clearance Cholesterol Import Plasma Lipoprotein Particle Clearance Protein Refolding Macromolecule Catabolic Process Sterol Transport Amyloid-beta Clearance By Cellular Catabolic Process Post-translational Protein Targeting To Membrane, Translocation Ubiquitin Protein Ligase Binding ERAD Pathway Cellular Response To Lipoprotein Particle Stimulus High-density Lipoprotein Particle Binding Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Catabolic Process Brush Border Membrane Regulation Of Defense Response Protein Metabolic Process Response To Hormone Apolipoprotein Binding Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Heat Shock Protein Binding Cell Surface Regulation Of Programmed Cell Death Cholesterol Transport Negative Regulation Of Programmed Cell Death	Cell Surface Integrin Binding External Side Of Plasma Membrane Platelet Alpha Granule Cell Adhesion Endoplasmic Reticulum Lumen Antigen Processing And Presentation Of Endogenous Antigen Cell-cell Adhesion Platelet Alpha Granule Lumen Extracellular Space Cellular Response To Oxygen-containing Compound Positive Regulation Of Immune System Process Signaling Receptor Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Regulation Of Extrinsic Apoptotic Signaling Pathway Extracellular Exosome Antibacterial Humoral Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Immune System Process MHC Class I Peptide Loading Complex Positive Regulation Of Cell Killing MHC Class I Protein Complex Peptide Antigen Assembly With MHC Class I Protein Complex Positive Regulation Of Gene Expression Response To Hormone Reproductive Behavior Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Response To Stress Negative Regulation Of Multicellular Organismal Process Tapasin-ERp57 Complex Positive Regulation Of Endocytosis Regulation Of T Cell Mediated Cytotoxicity Regulation Of Leukocyte Mediated Cytotoxicity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Platelet Aggregation Negative Regulation Of Signal Transduction Regulation Of Tumor Necrosis Factor Production Blood Coagulation Cellular Response To Amyloid-beta Apolipoprotein Binding Coagulation Signaling Receptor Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Tumor Necrosis Factor Production Heparan Sulfate Proteoglycan Binding
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