IAPP and RAMP1

Number of citations of the paper that reports this interaction (PubMedID 10385705)
0

Data Source:
HPRD (in vitro)

		IAPP	RAMP1
Description		islet amyloid polypeptide	receptor activity modifying protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Inclusion Body Neuronal Cell Body	Plasma Membrane Cell Surface Membrane Receptor Complex CGRP Receptor Complex
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Lipid Binding Identical Protein Binding Receptor Ligand Activity	Calcitonin Gene-related Peptide Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Calcitonin Gene-related Peptide Binding
	Biological Process	Apoptotic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Sensory Perception Of Pain Osteoclast Differentiation Negative Regulation Of Protein-containing Complex Assembly Protein Destabilization Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Bone Resorption Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Calcium-mediated Signaling Protein Homooligomerization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor 3 Signaling Pathway Negative Regulation Of Amyloid Fibril Formation Amyloid Fibril Formation	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Receptor Internalization Cellular Response To Hormone Stimulus Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane Amylin Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway
Pathways		Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors Amyloid fiber formation	G alpha (s) signalling events Calcitonin-like ligand receptors
Drugs		Copper	Pramlintide
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)	Obesity-related traits ( 23251661) Resting metabolic rate ( 28476931)
Interacting Genes		6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2	10 interacting genes: CALCA CALCR CALCRL DCLK3 IAPP MAL MS4A13 NKG7 SLC31A2 VIPR1
Entrez ID		3375	10267
HPRD ID		01005	05515
Ensembl ID		ENSG00000121351	ENSG00000132329
Uniprot IDs		P10997	E9PC20 O60894
PDB IDs		1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ 6UCJ 6UCK 6VW2 6Y1A 6ZRF 6ZRQ 6ZRR 7BG0 7M61 7M62 7M64 7M65 7YKW 7YL0 7YL3 7YL7 8AWT 8AZ0 8AZ1 8AZ2 8AZ3 8AZ4 8AZ5 8AZ6 8AZ7 8F0J 8F0K 8F2A 8F2B 8R4I 8YG2 9GZ6 9GZP 9GZS 9GZT 9GZW 9GZX 9GZY	2YX8 3N7P 3N7R 3N7S 4RWG 5V6Y 6D1U 6E3Y 6UMG 6ZHO 6ZIS 7KNT 7KNU 7P0F 7P0I 7TYF 7TYW 8AX5 8AX6 8AX7 9AUC
Enriched GO Terms of Interacting Partners?		Insulin Processing Amylin Receptor Signaling Pathway Calcitonin Family Receptor Signaling Pathway Insulin Metabolic Process Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Coreceptor Activity Cellular Response To Acadesine Islet Amyloid Polypeptide Processing Receptor Internalization Calcitonin Gene-related Peptide Binding Endopeptidase Activity Regulation Of Hormone Levels Transport Vesicle Secretory Granule Response To Chlorate Enkephalin Processing Adrenomedullin Binding CGRP Receptor Complex Serine-type Peptidase Activity Response To Hormone Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Proliferation Serine-type Endopeptidase Activity Adrenomedullin Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Basement Membrane Assembly Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Receptor 2 Signaling Pathway Adrenomedullin Receptor Complex Amylin Receptor 1 Signaling Pathway Positive Regulation Of Protein Glycosylation Amylin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Receptor-mediated Endocytosis Hormone Metabolic Process Protein Processing Protein Localization To Plasma Membrane Adrenomedullin Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Receptor Complex Glucose Mediated Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Transdifferentiation Response To Iron(II) Ion Regulation Of Protein Glycosylation Protein Localization To Cell Periphery Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Carbohydrate Mediated Signaling Calcium Ion Transport	Calcitonin Family Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcitonin Receptor Activity Amylin Receptor 3 Signaling Pathway Calcitonin Gene-related Peptide Receptor Activity Negative Regulation Of Bone Resorption G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Bone Remodeling Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Osteoclast Differentiation Regulation Of Bone Resorption Transmembrane Signaling Receptor Activity Regulation Of Bone Remodeling Regulation Of CAMP/PKA Signal Transduction Osteoclast Differentiation Negative Regulation Of Myeloid Leukocyte Differentiation Amylin Receptor Complex 2 Calcitonin Family Receptor Activity Positive Regulation Of Calcium-mediated Signaling Amylin Receptor Complex 1 Calcitonin Binding Regulation Of Copper Ion Transmembrane Transport Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Sucrose Stimulus Regulation Of Osteoclast Differentiation Receptor Internalization Regulation Of Tissue Remodeling Calcitonin Receptor Binding Amyloid-beta Binding Amylin Receptor Complex 3 G Protein-coupled Receptor Activity Adrenomedullin Binding CGRP Receptor Complex Negative Regulation Of Myeloid Cell Differentiation Regulation Of Calcium-mediated Signaling Amylin Receptor Activity Membrane Raft Polarization Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Hormone Activity
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