APOA4 and CMTM4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOA4	CMTM4
Description		apolipoprotein A4	CKLF like MARVEL transmembrane domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Cell Surface Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Synapse Extracellular Exosome Blood Microparticle Extracellular Vesicle	Membrane
	Molecular Function	Lipid Transporter Activity Copper Ion Binding Protein Binding Phospholipid Binding Lipid Binding Antioxidant Activity Phosphatidylcholine Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Cholesterol Transfer Activity	Protein Binding
	Biological Process	Innate Immune Response In Mucosa Lipid Transport Response To Stress Response To Lipid Hydroperoxide Leukocyte Cell-cell Adhesion Cholesterol Metabolic Process Positive Regulation Of Triglyceride Catabolic Process Peripheral Nervous System Axon Regeneration Lipid Catabolic Process Removal Of Superoxide Radicals Regulation Of Intestinal Cholesterol Absorption Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Response To Triglyceride Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Stilbenoid Lipoprotein Metabolic Process Cholesterol Homeostasis Hydrogen Peroxide Catabolic Process Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Lipid Homeostasis Acylglycerol Homeostasis Protein-lipid Complex Assembly
Pathways		Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs		Zinc Copper Zinc acetate
Diseases
GWAS		Apolipoprotein A-IV levels ( 27412012) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565) Coronary artery disease ( 29263402) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 26582766 20864672 20686565 19060906) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 20686565 20864672 19060911) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolic syndrome ( 30382898) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Total cholesterol levels ( 29615537 28334899 29403010) Triglyceride levels ( 26763881 32335043 32203549 29615537 28371326 28334899) Triglycerides ( 20139978 20686565 20864672 19074352 19060911 19060906 21909109 26582766 18193044 18193043)
Interacting Genes		6 interacting genes: AGTRAP CMTM4 CMTM5 GPLD1 HSP90AA1 MAGEA6	20 interacting genes: APOA4 APPL1 COQ8A DAPK1 DGCR6L DIABLO HSBP1L1 MIDN MRPL2 PBX3 PTPN9 SMG9 SNX1 SPG21 SSX3 STAR TBRG4 TCEA2 TTPA ZFYVE21
Entrez ID		337	146223
HPRD ID		00130	07435
Ensembl ID		ENSG00000110244	ENSG00000183723
Uniprot IDs		P06727	Q8IZR5
PDB IDs		3S84
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity CTP Binding DATP Binding Cellular Response To Triglyceride Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Histone Deacetylase Binding Positive Regulation Of High-density Lipoprotein Particle Clearance Rho GDP-dissociation Inhibitor Binding Positive Regulation Of Phosphatase Activity Negative Regulation Of Triglyceride Catabolic Process Response To Triglyceride Phospholipase D Activity Positive Regulation Of Dephosphorylation Hematopoietic Stem Cell Migration To Bone Marrow Sperm Mitochondrial Sheath Telomerase Holoenzyme Complex Assembly Angiotensin Type II Receptor Activity Positive Regulation Of Protein Catabolic Process Hematopoietic Stem Cell Migration Regulation Of Phosphatase Activity Positive Regulation Of Protein Transport Chaperone-mediated Autophagy Positive Regulation Of Cardiac Muscle Contraction Nitric-oxide Synthase Regulator Activity Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding
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