HTR4 and CLDN10

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR4	CLDN10
Description		5-hydroxytryptamine receptor 4	claudin 10
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse	Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Tight Junction Anchoring Junction
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity	Structural Molecule Activity Protein Binding Identical Protein Binding Paracellular Tight Junction Channel Activity
	Biological Process	System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Mucus Secretion Large Intestinal Transit Regulation Of Postsynapse Assembly	Monoatomic Ion Transport Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Monoatomic Ion Transport Bicellular Tight Junction Assembly Paracellular Transport
Pathways		Serotonin receptors G alpha (s) signalling events	Tight junction interactions Developmental Lineage of Pancreatic Ductal Cells
Drugs		Dihydroergotamine Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases
GWAS		Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 30804561 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010835 20010834) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)	Dental caries (decayed and filled deciduous teeth) ( 31533690) Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483) Psychosis proneness (hypomanic personality scale) ( 28525603)
Interacting Genes		18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7	11 interacting genes: BEST2 CISD2 HSD17B13 HTR4 LMNA OPRM1 PEX12 REEP1 TMEM14B TMEM9 VKORC1
Entrez ID		3360	9071
HPRD ID		09074	13063
Ensembl ID		ENSG00000164270	ENSG00000134873
Uniprot IDs		A0A2D3FAF9 Q13639	P78369
PDB IDs		5EM9 7XT8 7XT9 7XTA
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Large Intestinal Transit Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Intracellularly Ligand-gated Monoatomic Ion Channel Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Endoplasmic Reticulum Cellular Response To Morphine Peroxisomal Importomer Complex Ligand-gated Monoatomic Cation Channel Activity Bicarbonate Channel Activity Ligand-gated Monoatomic Anion Channel Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Steroid Dehydrogenase Activity
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