HSPB2 and CYP1B1

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		HSPB2	CYP1B1
Description		heat shock protein family B (small) member 2	cytochrome P450 family 1 subfamily B member 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Heme Binding Metal Ion Binding Testosterone 6-beta-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process	Angiogenesis Trabecular Meshwork Development Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Catabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Cell Adhesion Steroid Metabolic Process Estrogen Metabolic Process Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Toxin Metabolic Process Response To Toxic Substance Positive Regulation Of Vascular Endothelial Growth Factor Production Sterol Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Collagen Fibril Organization Negative Regulation Of Cell Migration Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Adhesion Mediated By Integrin Xenobiotic Catabolic Process Hormone Metabolic Process Benzene-containing Compound Metabolic Process Retinol Metabolic Process Retinal Metabolic Process Positive Regulation Of Apoptotic Process Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Membrane Lipid Catabolic Process Blood Vessel Morphogenesis Retina Vasculature Development In Camera-type Eye Retinal Blood Vessel Morphogenesis Cellular Response To Hydrogen Peroxide Endothelial Cell-cell Adhesion Omega-hydroxylase P450 Pathway Olefinic Compound Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Endogenous sterols Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective CYP1B1 causes Glaucoma
Drugs			Genistein 2-Methoxyestradiol Naringenin Quercetin beta-Naphthoflavone Flavone Cannabidiol Nabiximols
Diseases			Primary open angle glaucoma
GWAS		Hip circumference adjusted for BMI ( 34021172)	Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Basal cell carcinoma ( 31174203 33549134) Central corneal thickness ( 32528159) Cutaneous malignant melanoma ( 26237428 32341527) Frontal fibrosing alopecia ( 30850646) Keratinocyte cancer (MTAG) ( 31174203) Melanoma ( 28212542) Metabolite levels ( 23823483) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480 32341527) Parkinson's disease ( 26227905)
Interacting Genes		110 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATM ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DDX10 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	1 interacting genes: HSPB2
Entrez ID		3316	1545
HPRD ID		03712	03464
Ensembl ID		ENSG00000170276	ENSG00000138061
Uniprot IDs		A8KAH6 Q16082	Q16678 Q53TK1
PDB IDs		6F2R	3PM0 6IQ5
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding	Somatic Muscle Development Protein Refolding Structural Constituent Of Eye Lens Response To Unfolded Protein Response To Heat Enzyme Activator Activity Unfolded Protein Binding Muscle Structure Development Response To Temperature Stimulus Protein Folding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?