HSPA8 and SAYSD1

Number of citations of the paper that reports this interaction (PubMedID 36848233)
56

Data Source:
BioGRID (pull down)

		HSPA8	SAYSD1
Description		heat shock protein family A (Hsp70) member 8	SAYSVFN motif domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Secretory Granule Lumen Melanosome Lysosomal Lumen Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Exosome Blood Microparticle Lumenal Side Of Lysosomal Membrane Protein Folding Chaperone Complex Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Cadherin Binding Receptor Ligand Activity Unfolded Protein Binding Protein-folding Chaperone Binding C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity ATP-dependent Protein Folding Chaperone	UFM1-modified Protein Reader Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding Autophagy Response To Unfolded Protein Signal Transduction RNA Splicing Cellular Response To Starvation Negative Regulation Of Signal Transduction Protein Catabolic Process Positive Regulation Of Cell Migration Regulation Of Protein Stability Cellular Response To Stress Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Refolding Regulation Of Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription ATP Metabolic Process Negative Regulation Of Cellular Component Organization Membrane Organization Regulation Of Protein Complex Stability Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Cellular Response To Steroid Hormone Stimulus Clathrin Coat Disassembly Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Supramolecular Fiber Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Protein Import Chaperone-mediated Autophagy Translocation Complex Disassembly	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Rescue Of Stalled Ribosome
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis CHL1 interactions AUF1 (hnRNP D0) binds and destabilizes mRNA Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation mRNA Splicing - Major Pathway Clathrin-mediated endocytosis Protein methylation GABA synthesis, release, reuptake and degradation Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy Respiratory syncytial virus genome transcription PKR-mediated signaling
Drugs		Dasatinib (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Copper Artenimol
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010 32888494) Postoperative acute renal failure after cardiac surgery ( 30678657) Red cell distribution width ( 32888494) Serum metabolite levels ( 33031748)	Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Coronary artery disease ( 32469254) Diastolic blood pressure ( 27841878) Protein C levels ( 28082259)
Interacting Genes		92 interacting genes: ABI1 AIPL1 ALDOB APOB ATM BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DPP3 DYNLL1 EGFR ERBB3 ERH ESR1 FANCC FBP1 FNDC3B FOXP1 GAK GCH1 GOT2 H3C1 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTN3 HTT IL32 JAK2 JUN LALBA LINC01554 MAPK8 MAPT NEDD8 NMI NOA1 PHC1 PPID PTEN PTPRF RAF1 RB1 REL RGS2 RNF26 SAYSD1 SIRPA SNCA SP1 SRRT ST13 STAT1 STIP1 STMN1 STUB1 SUMO2 SUMO4 TADA3 TCERG1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 USP40 VHL WEE2-AS1 YWHAG YWHAQ	5 interacting genes: HSPA8 RPL26 RPL5 RPS2 UFM1
Entrez ID		3312	55776
HPRD ID		07205	12892
Ensembl ID		ENSG00000109971	ENSG00000112167
Uniprot IDs		P11142 Q53HF2 V9HW22	Q9NPB0
PDB IDs		3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4H5N 4H5R 4H5T 4H5V 4H5W 4HWI 4KBQ 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 6B1I 6B1M 6B1N 6ZYJ
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Regulation Of Protein Stability Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Folding Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Stabilization Negative Regulation Of Apoptotic Process Enzyme Binding Response To Stress Negative Regulation Of Programmed Cell Death Cytosol Apoptotic Process Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Cell Death Positive Regulation Of Programmed Cell Death Adenyl-nucleotide Exchange Factor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Protein Modification Process Heat Shock Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Hsp70 Protein Binding Cellular Response To Stress Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Folding Chaperone Complex Negative Regulation Of Intracellular Signal Transduction Response To Heat Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Catabolic Process Nucleus Response To Peptide Positive Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome MRNA 5'-UTR Binding Regulation Of Ubiquitin-protein Transferase Activity Nucleolus Ribosomal Large Subunit Biogenesis Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Protein Metabolic Process Chaperone-mediated Autophagy Translocation Complex Disassembly RNA Binding Regulation Of Translation Involved In Cellular Response To UV Regulation Of Signal Transduction By P53 Class Mediator Lumenal Side Of Lysosomal Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Intracellular Signal Transduction Positive Regulation Of Translation Regulation Of Protein Import Extracellular Exosome Positive Regulation Of Protein Metabolic Process Ribonucleoprotein Complex Biogenesis Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy RNA Processing C3HC4-type RING Finger Domain Binding Clathrin Coat Disassembly Regulation Of Protein Ubiquitination RRNA Processing Negative Regulation Of Protein Neddylation Protein K69-linked Ufmylation ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification RRNA Metabolic Process Chaperone-mediated Autophagy Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Ufmylation Autophagy Ubiquitin Protein Ligase Binding 5S RRNA Binding Cadherin Binding Negative Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin Ligase Inhibitor Activity
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