HSPA4 and ST13

Number of citations of the paper that reports this interaction (PubMedID 27708256)
57

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down)

		HSPA4	ST13
Description		heat shock protein family A (Hsp70) member 4	ST13 Hsp70 interacting protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Organelle Extracellular Exosome	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding ATP-dependent Protein Folding Chaperone	Protein Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity Protein Dimerization Activity
	Biological Process	Protein Folding Response To Unfolded Protein Protein Import Into Mitochondrial Matrix Chaperone-mediated Protein Complex Assembly	Protein Folding Response To Bacterium
Pathways		Regulation of HSF1-mediated heat shock response	Regulation of HSF1-mediated heat shock response
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		A body shape index ( 34021172) Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 31928498 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Feeling nervous ( 29500382) Refractive error ( 32231278)
Interacting Genes		72 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BRMS1 CALM1 CD40 CDC73 CDKN2A CEBPA CSNK1A1 CSNK2A1 DDIT4 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSF2 HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NEDD8 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 POU6F2 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 PTEN RAF1 RAP1A REL RELA SENP8 SGTA SIRPA SMAD3 ST13 STIP1 STK4 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE2M UBE3A	25 interacting genes: ALB APOE ASF1A CD101 CDC42 CTRC CXCR2 F2 GRIK1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 NOS3 OGT OLFM2 PSEN1 PTGER4 RBFOX2 SMAD2 SNCA SRSF8 TTR VAV2
Entrez ID		3308	6767
HPRD ID		09025	08426
Ensembl ID		ENSG00000170606	ENSG00000100380
Uniprot IDs		P34932	A0A140VKA6 B4E0U6 P50502 Q0IJ56
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cytosol Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Primary Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Protein Catabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Response To Lipid Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Regulation Of Protein Stability Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Lipid Negative Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Signaling Pathway	ATP-dependent Protein Folding Chaperone Protein-containing Complex Regulation Of Protein-containing Complex Assembly Blood Microparticle C3HC4-type RING Finger Domain Binding Regulation Of Biological Quality Regulation Of Supramolecular Fiber Organization ATP-dependent Protein Disaggregase Activity Protein Refolding Negative Regulation Of Cellular Component Organization Tau Protein Binding Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Protein Folding Chaperone Intracellular Signal Transduction Negative Regulation Of Platelet Activation Inclusion Body Response To Stress Regulation Of Inclusion Body Assembly Positive Regulation Of Supramolecular Fiber Organization Chaperone-mediated Protein Complex Assembly Signal Transduction Disordered Domain Specific Binding Response To Unfolded Protein Response To Heat Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Protein Folding Positive Regulation Of Protein Catabolic Process Calcium Ion Homeostasis Regulation Of Proteolysis Aggresome Negative Regulation Of Protein Metabolic Process Positive Regulation Of Signaling Intracellular Signaling Cassette Positive Regulation Of Amyloid Fibril Formation Unfolded Protein Binding Response To Hormone Ficolin-1-rich Granule Lumen Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Receptor Ligand Activity Regulation Of Immune System Process Chaperone-mediated Autophagy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Cellular Response To Heat Positive Regulation Of Microtubule Nucleation
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