HSPA1A and ACE2

Number of citations of the paper that reports this interaction (PubMedID 39187102)
0

Data Source:
BioGRID (pull down)

		HSPA1A	ACE2
Description		heat shock protein family A (Hsp70) member 1A	angiotensin converting enzyme 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cilium Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Brush Border Membrane Cell Projection Membrane Raft Extracellular Exosome
	Molecular Function	Nucleotide Binding Virus Receptor Activity G Protein-coupled Receptor Binding Transcription Corepressor Activity RNA Binding Signaling Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Denatured Protein Binding Ubiquitin Protein Ligase Binding Death Receptor Agonist Activity Histone Deacetylase Binding Protein Folding Chaperone Cadherin Binding Receptor Ligand Activity Unfolded Protein Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Disordered Domain Specific Binding Transcription Regulator Inhibitor Activity ATP-dependent Protein Disaggregase Activity ATP-dependent Protein Folding Chaperone	Virus Receptor Activity Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding Transporter Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Protein Folding Response To Unfolded Protein Lysosomal Transport Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of RNA Splicing Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation ATP Metabolic Process Symbiont Entry Into Host Cell Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Cellular Heat Acclimation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Microtubule Nucleation Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitotic Spindle Assembly Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Angiotensin Maturation Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Tryptophan Transport Viral Life Cycle Receptor-mediated Endocytosis Of Virus By Host Cell Viral Translation Regulation Of Vasoconstriction Regulation Of Cell Population Proliferation Ceramide Biosynthetic Process Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Amino Acid Transport Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Membrane Fusion Negative Regulation Of ERK1 And ERK2 Cascade Blood Vessel Diameter Maintenance Entry Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of L-proline Import Across Plasma Membrane Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt) Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt)	Metabolism of Angiotensinogen to Angiotensins Attachment and Entry Potential therapeutics for SARS Attachment and Entry Attachment and Entry Induction of Cell-Cell Fusion
Drugs			Chloroquine Hydroxychloroquine SPP1148 Bromhexine N-(2-Aminoethyl)-1-aziridineethanamine
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Schizophrenia ( 30285260) Systemic lupus erythematosus ( 32771030) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		96 interacting genes: ACE2 AIFM1 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAAF4 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJB4 DNAJC3 EGFR EIF2AK2 EIF4ENIF1 ERBB2 ERBB3 FANCC FILNC1 FNDC3B FOS FTCD GPR37 GRIN1 GRIN2D HAP1 HCFC1 HEMGN HIVEP1 HMGA1 HSBP1 HSF1 HSPA8 HSPBP1 IKBKG IL3 INS KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 OGT PEX5 PGR PLG POT1 PPP1R15A PRKCA PSMC5 PTGES3 PTMA PTPRF RAP1A RAPGEF2 RHOA SAE1 SLC13A1 SLC5A1 SNCB SNRK SOX9 ST13 STIP1 STUB1 SUMO2 TCERG1 TGM2 TOMM70 TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 UBE2D3 XIAP YWHAB YWHAG YWHAQ YWHAZ	48 interacting genes: AGT AGTR1 AGTR2 APOE BTN3A1 BTN3A2 BTN3A3 CALM1 CAMP DEFA1 DEFA5 DLEU2 ELANE GHRL GRM2 H2AC4 HRH1 HSPA1A KDM1A LTF LYZ MAP4K3 MAS1 MAST1 MAST2 MMP14 NHERF1 NHERF2 NTS PARD3 PDZK1 PRMT5 PTPN3 SCRIB SHANK1 SHANK2 SHANK3 SHROOM2 SKP2 SLC6A19 SNX17 SNX27 TAMALIN TMPRSS11A TMPRSS11D TMPRSS2 UBR4 USP50
Entrez ID		3303	59272
HPRD ID		00774	02274
Ensembl ID		ENSG00000204389	ENSG00000130234
Uniprot IDs		A8K5I0 B3KTT5 P0DMV8 P0DMV9	A0A7I2V4H0 Q9BYF1
PDB IDs		1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 3Q49 4IO8 4J8F 4PO2 4WV5 4WV7 5AQW 5AQX 5AQY 5AQZ 5AR0 5BN8 5BN9 5BPL 5BPM 5BPN 5GJJ 5MKR 5MKS 5XI9 5XIR 6FDT 6FHK 6G3R 6G3S 6JPV 6K39 6ZYI 7F4X 7F4Z 7F50 7FGM 7GY4 7GY5 7GY6 7GY7 7GY8 7GY9 7GYA 7GYB 7GYC 7GYD 7GYE 7GYF 7GYG 7GYH 7GYI 7GYJ 7GYK 7GYL 7GYM 7GYN 7GYO 7GYP 7GYQ 7GYR 7GYS 7GYT 7GYU 7GYV 7GYW 7GYX 7KW7 7Q4R	1R42 1R4L 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL 6ACG 6ACJ 6ACK 6CS2 6LZG 6M0J 6M17 6M18 6M1D 6VW1 7A91 7A92 7A94 7A95 7A96 7A97 7A98 7BH9 7CT5 7DDO 7DDP 7DF4 7DMU 7DQA 7DRV 7DWX 7DX4 7DX5 7DX6 7DX7 7DX8 7DX9 7E7E 7EDJ 7EFP 7EFR 7EKC 7EKE 7EKF 7EKG 7EKH 7FDG 7FDH 7FDI 7FEM 7JVO 7KJ2 7KJ3 7KJ4 7KMB 7KMS 7KMZ 7KNB 7KNE 7KNH 7KNI 7L0N 7L7F 7LO4 7MJM 7MJN 7NXC 7P19 7P55 7P8I 7P8J 7PKI 7R0Z 7R10 7R11 7R12 7R1A 7RPV 7SN0 7SXX 7SXY 7SXZ 7SY0 7SY1 7SY2 7SY3 7SY4 7SY5 7SY6 7SY7 7SY8 7T9K 7T9L 7TEW 7TEX 7TEZ 7TF0 7TN0 7U0N 7UFK 7UFL 7V61 7V7Z 7V80 7V81 7V82 7V83 7V84 7V85 7V86 7V87 7V88 7V89 7V8A 7V8B 7VIB 7VX4 7VX5 7VX9 7VXA 7VXB 7VXC 7VXD 7VXF 7VXK 7VXM 7W98 7W99 7W9B 7W9C 7W9I 7WBL 7WBP 7WBQ 7WGB 7WGC 7WHH 7WK4 7WK5 7WK6 7WNM 7WPA 7WPB 7WPC 7WS8 7WS9 7WSA 7WVP 7WVQ 7XAZ 7XB0 7XB1 7XBF 7XBG 7XBH 7XCH 7XCI 7XCP 7XID 7XO7 7XO8 7XO9 7XWA 7Y1Y 7Y1Z 7Y20 7Y21 7Y75 7Y76 7Y9Z 7YA0 7YA1 7YDI 7YEG 7YHW 7YJ3 7YR2 7YR3 7YR4 7ZDQ 7ZF7 8AQS 8ASY 8B9P 8BFW 8BN1 8BYJ 8DF5 8DLJ 8DLK 8DLM 8DLN 8DLP 8DLQ 8DLU 8DLV 8DM5 8DM6 8DV1 8DV2 8E7M 8FXB 8FXC 8H06 8H5C 8HRK 8HRL 8HRN 8HRU 8I91 8I92 8I93 8I9B 8I9C 8I9D 8I9E 8I9F 8I9G 8I9H 8IF2 8IOU 8IOV 8JJE 8JWH 8JYN 8JYO 8JYP 8P2W 8P2X 8P2Y 8P2Z 8P30 8P31 8QSQ 8S9G 8SPH 8SPI 8TOQ 8TOR 8TOS 8TOT 8TOU 8UZE 8VKO 8VKP 8VQR 8WBY 8WBZ 8WDR 8WDS 8WDY 8WDZ 8WE0 8WE1 8WE4 8WGV 8WGW 8WHS 8WHU 8WHZ 8WLZ 8WM3 8WP8 8WRH 8WRL 8WRM 8WRO 8WSR 8WTD 8WTJ 8WYH 8XAL 8XLM 8XLN 8XN2 8XN3 8XN5 8XNF 8XNK 8XSF 8XSJ 8XUY 8XUZ 8XV0 8XV1 8XVM 8XXW 8XY9 8XYE 8XYG 8XYO 8Y16 8Y18 8Y6A 8YZB 8YZC 8YZD 8YZE 8Z3W 8Z4X 8Z64 8Z6A 8Z7B 8Z7P 8ZBQ 9FMM 9IU1 9IUP 9IUQ 9IUU 9JJ6
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Protein-folding Chaperone Binding Protein Folding Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Protein Folding Chaperone Complex Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Cytoplasm Intracellular Signal Transduction Heat Shock Protein Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Protein-containing Complex Intracellular Signaling Cassette Ubiquitin Protein Ligase Binding Response To Stress Regulation Of Protein Metabolic Process Hsp70 Protein Binding Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Adenyl-nucleotide Exchange Factor Activity Apoptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Stability Response To Heat Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Programmed Cell Death Negative Regulation Of RNA Metabolic Process Cell Death Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Response To Temperature Stimulus Neuron Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction	Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Angiotensin Type II Receptor Activity Plasma Membrane Biological Process Involved In Interaction With Symbiont Killing By Host Of Symbiont Cells Killing Of Cells Of Another Organism Synaptic Receptor Adaptor Activity Positive Regulation Of Signaling Angiotensin-activated Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Cytokine Production Signal Transduction Regulation Of System Process Defense Response To Fungus Positive Regulation Of Cell Communication Vascular Process In Circulatory System Response To Fungus Cell Killing Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Nitric Oxide-cGMP-mediated Signaling Circulatory System Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Signaling Positive Regulation Of Signal Transduction Serine-type Endopeptidase Activity Antimicrobial Humoral Response Defense Response To Gram-negative Bacterium G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Type 2 Metabotropic Glutamate Receptor Binding Positive Regulation Of Cytokine Production Positive Regulation Of Developmental Process Low-density Lipoprotein Particle Remodeling Localization Within Membrane Regulation Of Cell Communication Brush Border Membrane Defense Response To Gram-positive Bacterium Renin-angiotensin Regulation Of Aldosterone Production Nitric Oxide Mediated Signal Transduction Extracellular Exosome Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Synaptic Plasticity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Specific Granule Lumen Type 3 Metabotropic Glutamate Receptor Binding
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