HSF4 and CNOT1

		HSF4	CNOT1
Description		heat shock transcription factor 4	CCR4-NOT transcription complex subunit 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Speck	P-body Extracellular Space Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Nuclear Estrogen Receptor Binding Nuclear Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Lens Fiber Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Translation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance
Pathways			Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) PR interval ( 32439900) Pulse pressure ( 30224653) QT interval ( 30679814 19305408 29874175 24952745 22726844) Schizophrenia ( 30285260 29483656 25056061) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		46 interacting genes: ACTMAP AKAP8L ALKBH4 BBS2 C10orf55 CDK2AP2 CNOT1 DAXX DUSP26 FAM168B FAM200C FOXH1 FOXI1 GFOD1 HGS INTS11 KRT31 KRT37 KRT38 KRT40 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP6-2 MAPK1 MAPK14 MAPK3 MAPK8 MKRN3 NHLRC4 NUDT21 NUP62 OIP5 PIH1D2 PITX1 PLA2G10 PPFIBP2 SESTD1 SLC27A5 SMARCA4 SOX10 STOML2 TPM3 UFSP1 YTHDF1 ZMYND12	17 interacting genes: AMFR BBS2 CDC42 CEBPA CNOT2 CNOT3 CNOT4 CNOT8 DDX6 HSF4 NANOS3 NOD2 OBI1 PPARG RARA RXRA THRB
Entrez ID		3299	23019
HPRD ID		03896	11999
Ensembl ID		ENSG00000102878	ENSG00000125107
Uniprot IDs		Q9ULV5	A5YKK6
PDB IDs		6J6V 6J6W	4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA 7VOI 8BFI 8FY3 9FL8
Enriched GO Terms of Interacting Partners?		Intermediate Filament MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Keratin Filament Protein Binding Structural Constituent Of Skin Epidermis Interleukin-34-mediated Signaling Pathway Positive Regulation Of Cyclase Activity Nuclear Androgen Receptor Binding Intermediate Filament Organization Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Anatomical Structure Morphogenesis Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Lipopolysaccharide-mediated Signaling Pathway Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Morphogenesis Of An Epithelium Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Senescence Tissue Morphogenesis Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Glial Cell Development Negative Regulation Of Cholesterol Efflux Regulation Of Gene Expression P53 Binding Regulation Of Golgi Organization Pseudopodium Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Negative Regulation Of Cholesterol Transport	CCR4-NOT Complex Negative Regulation Of Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Biosynthetic Process Retinoic Acid Receptor Signaling Pathway CCR4-NOT Core Complex Negative Regulation Of Macromolecule Metabolic Process P-body MRNA Metabolic Process Negative Regulation Of Metabolic Process MRNA Transcription By RNA Polymerase II Cell Differentiation RNA Polymerase II Transcription Regulator Complex Nuclear Receptor Activity MRNA Transcription Negative Regulation Of Gene Expression Cellular Developmental Process RNA Metabolic Process Regulation Of Translation Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process DNA Binding Domain Binding MRNA Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Lipoprotein Transport Myeloid Leukocyte Differentiation Response To Nutrient Hormone-mediated Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Post-transcriptional Regulation Of Gene Expression LBD Domain Binding Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Transcription By RNA Polymerase II Regulatory NcRNA-mediated Gene Silencing Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Macromolecule Catabolic Process Enzyme Binding RNA Catabolic Process Chromatin Nucleic Acid Metabolic Process Protein Autoubiquitination Regulation Of Protein Metabolic Process
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