BIRC2 and GAS1

Number of citations of the paper that reports this interaction (PubMedID 11906213)
0

Data Source:
HPRD (in vivo)

		BIRC2	GAS1
Description		baculoviral IAP repeat containing 2	growth arrest specific 1
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GO Annotations	Cellular Component	XY Body Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Protein-containing Complex CD40 Receptor Complex	Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity FBXO Family Protein Binding	Protein Binding Oxysterol Binding
	Biological Process	Protein Polyubiquitination Response To Hypoxia Placenta Development Apoptotic Process Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of RIG-I Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Inflammatory Response Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein Polyubiquitination Response To Bleomycin Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Processing Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Mitotic Cell Cycle Developmental Growth Regulation Of Cell Cycle Regulation Of ER To Golgi Vesicle-mediated Transport
Pathways		Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1	Ligand-receptor interactions Activation of SMO
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Heel bone mineral density ( 30598549) Insulin resistance/response ( 21901158) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		81 interacting genes: ABHD17A BIRC5 BIRC6 BLK BMX BOLA1 BOLA2 BOLA2B CASP3 CASP7 CASP9 CBLC CD40 CDC42 CSE1L CTBP2 DIABLO DZIP3 E2F1 EAF2 EIF4E EXOSC5 FBXO7 FDX1 FTCD GAS1 GCC1 GFAP GLMN GSPT1 HSP90B1 HTRA2 IGF2BP1 IKBKE IKBKG JUP KDM1A LNX1 LTBR MAD1L1 MAGEA11 MAP3K2 MAP3K3 MAP3K5 NMB NXF1 OTUB1 PACS2 PCSK9 PFN2 PPM1K RAC1 RAF1 RFC5 RHOA RIPK2 RIPK3 RIPK4 RNF181 RUNX1T1 TCAF1 TNF TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 TUFT1 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2N UBE2Q2 UBE2S UBE2V1 UBE2W	7 interacting genes: BIRC2 COL15A1 CYB5R3 DLK1 ERRFI1 PTPRA SHH
Entrez ID		329	2619
HPRD ID		03419	00747
Ensembl ID		ENSG00000110330	ENSG00000180447
Uniprot IDs		Q13490	P54826
PDB IDs		1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4KMN 4LGE 4LGU 4MTI 4MU7 5M6N 6EXW 6HPR 6W74 6W7O 6W8I 7QGJ 7TRL 7TRM 8DSF 8DSO	7RHQ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Cell Death Apoptotic Process Programmed Cell Death Protein Modification Process Post-translational Protein Modification Protein Ubiquitination Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Regulation Of Signaling Protein Metabolic Process Regulation Of Apoptotic Process Macromolecule Catabolic Process Regulation Of Cell Communication Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Polyubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Protein Catabolic Process Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Transferase Activity Protein-containing Complex Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Regulation Of Protein Modification Process Cytoplasm Proteolysis Thioesterase Binding Proteolysis Involved In Protein Catabolic Process Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Intrinsic Apoptotic Signaling Pathway CD40 Receptor Complex Nucleotide Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Modification-dependent Protein Catabolic Process	Lung Epithelium Development Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Collagen Type XV Trimer Steroid Metabolic Process Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Skin Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Left Lung Development Positive Regulation Of Sclerotome Development Right Lung Development Vasculature Development Polarity Specification Of Anterior/posterior Axis Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Primary Prostatic Bud Elongation Tracheoesophageal Septum Formation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Protein K48-linked Ubiquitination FBXO Family Protein Binding Nitric-oxide Synthase Complex Cholesterol Metabolic Process Sterol Metabolic Process Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Intein-mediated Protein Splicing Cholesterol-protein Transferase Activity Prostate Epithelial Cord Elongation Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Skeletal Muscle Cell Proliferation Bud Outgrowth Involved In Lung Branching Ventral Midline Development Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Specification Of Axis Polarity Trachea Morphogenesis Trachea Development Negative Regulation Of Dopaminergic Neuron Differentiation Hindgut Morphogenesis Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Positive Regulation Of Protein Monoubiquitination Nitrite Reductase (NO-forming) Activity Salivary Gland Cavitation Mesenchymal Cell Proliferation Involved In Lung Development Epithelial-mesenchymal Cell Signaling Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Trunk Neural Crest Cell Migration
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