APEX1 and SRPK1

Number of citations of the paper that reports this interaction (PubMedID 23602568)
0

Data Source:
BioGRID (enzymatic study)

		APEX1	SRPK1
Description		apurinic/apyrimidinic endodeoxyribonuclease 1	SRSF protein kinase 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Ribosome Nuclear Speck Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Nuclear Matrix Nuclear Speck
	Molecular Function	DNA Binding Damaged DNA Binding Double-stranded Telomeric DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Phosphodiesterase I Activity Uracil DNA N-glycosylase Activity Protein Binding Phosphoric Diester Hydrolase Activity 3'-5'-DNA Exonuclease Activity Double-stranded DNA Exodeoxyribonuclease Activity Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Oxidoreductase Activity Hydrolase Activity Chromatin DNA Binding Deoxyribonuclease (pyrimidine Dimer) Activity Metal Ion Binding Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands DNA-(abasic Site) Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Telomere Maintenance DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Catabolic Process DNA Recombination DNA Damage Response Regulation Of Apoptotic Process Regulation Of MRNA Stability Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Cell Redox Homeostasis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Base-excision Repair	Spliceosomal Complex Assembly MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Cell Differentiation Sperm DNA Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing
Pathways		Displacement of DNA glycosylase by APEX1 POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA-Dependent Long Patch Base Excision Repair Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)	Maturation of nucleoprotein Replacement of protamines by nucleosomes in the male pronucleus
Drugs		Lucanthone
Diseases
GWAS		Menopause (age at onset) ( 26414677)	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		46 interacting genes: ANP32A ANP32CP APP CDC42 CEBPA CSNK2A1 DCTN1 EP300 FBXO7 FEN1 GZMA GZMK HDAC1 HIF1A HMGA1 HMGA2 HMGB2 HNRNPL HOXC13 HSPA1A LINC01554 MCL1 MDM2 MUTYH NFE2L2 NME1 NUDT3 NXF2 PCNA POLB POLR3D SET SLC25A21-AS1 SRPK1 SRPK2 TCF21 TERF1 TERF2 TERF2IP TP53 TXN UBE2I UBR3 XRCC1 XRCC5 XRCC6	169 interacting genes: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARK2N ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf87 C16orf78 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CIMAP1D CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG JHY KCNAB1 KCNN2 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L3 MACROH2A1 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MAPT MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PPIL3 PRM1 PRPF38A PTK2 PTPN2 RBM23 RBMS2 RIMS4 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SANBR SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRRM1 SRSF1 SRSF10 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP7 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2
Entrez ID		328	6732
HPRD ID		00136	15992
Ensembl ID		ENSG00000100823	ENSG00000096063
Uniprot IDs		P27695 Q5TZP7	Q96SB4
PDB IDs		1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM 4LND 4QH9 4QHD 4QHE 5CFG 5DFF 5DFH 5DFI 5DFJ 5DG0 5WN0 5WN1 5WN2 5WN3 5WN4 5WN5 6BOQ 6BOR 6BOS 6BOT 6BOU 6BOV 6BOW 6MK3 6MKK 6MKM 6MKO 6P93 6P94 6W0Q 6W2P 6W3L 6W3N 6W3Q 6W3U 6W43 6W4I 6W4T 7LPG 7LPH 7LPI 7LPJ 7MCR 7MEV 7SUV 7SVB 7TC2 7TC3 7TR7 7U50 9DP1 9DP2 9DP3 9DP4	1WAK 1WBP 3BEG 4WUA 5MXX 5MY8 5NNG 5XV7 6FAD 7DD1 7PQS 7ZKS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Nucleic Acid Metabolic Process DNA Metabolic Process 5'-deoxyribose-5-phosphate Lyase Activity Protein-containing Complex DNA Damage Response Damaged DNA Binding Nuclear Telomere Cap Complex Macromolecule Metabolic Process Enzyme Binding Negative Regulation Of DNA Metabolic Process Cellular Response To Stress Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Telomere Maintenance Negative Regulation Of Metabolic Process DNA Binding Base-excision Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Negative Regulation Of RNA Metabolic Process Response To Stress Chromosome Organization Transcription Cis-regulatory Region Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Telomere Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Double-stranded Telomeric DNA Binding DNA Repair Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Telomeric DNA Binding Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Biosynthetic Process Response To Radiation Chromosome, Telomeric Region Regulation Of Primary Metabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Metabolic Process DNA Binding, Bending Protein-DNA Complex Double-strand Break Repair DNA Biosynthetic Process	RNA Splicing Regulation Of MRNA Processing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Nucleoplasm Nucleus MRNA Binding Nuclear Speck Nucleic Acid Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleic Acid Binding Protein Kinase Activity Negative Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Kinase Activity Negative Regulation Of RNA Splicing Spliceosomal Complex Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Protein-RNA Complex Assembly Pre-mRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Alternative MRNA Splicing, Via Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific MRNA Binding Main Axon Response To Starvation Regulation Of Toll Signaling Pathway Catalytic Step 2 Spliceosome Protein Autophosphorylation IkappaB Kinase Complex Positive Regulation Of Viral Process Protein Phosphorylation Positive Regulation Of RNA Splicing
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