HRAS and IKZF3

Number of citations of the paper that reports this interaction (PubMedID 10369681)
53

Data Source:
HPRD (in vitro, in vivo)

		HRAS	IKZF3
Description		HRas proto-oncogene, GTPase	IKAROS family zinc finger 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Glutamatergic Synapse GTPase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-membrane Adaptor Activity Phospholipase C Activator Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding
	Biological Process	MAPK Cascade Regulation Of Transcription By RNA Polymerase II Endocytosis Chemotaxis Signal Transduction Cell Surface Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Schwann Cell Development Positive Regulation Of Cell Migration Positive Regulation Of Type II Interferon Production Regulation Of Actin Cytoskeleton Organization T-helper 1 Type Immune Response Regulation Of Cell Population Proliferation Myelination Defense Response To Protozoan Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Epithelial Cell Proliferation T Cell Receptor Signaling Pathway Neuron Apoptotic Process Regulation Of Cell Cycle Adipose Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Gamma Radiation Positive Regulation Of Wound Healing Positive Regulation Of Protein Targeting To Membrane Cellular Senescence Oncogene-induced Cell Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Ruffle Assembly Positive Regulation Of MiRNA Metabolic Process	Regulation Of Transcription By RNA Polymerase II Mesoderm Development Response To Bacterium B Cell Differentiation T Cell Differentiation Regulation Of B Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Regulation Of B Cell Differentiation Regulation Of Lymphocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		SOS-mediated signalling Activation of RAS in B cells Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signaling by SCF-KIT Signalling to RAS p38MAPK events p38MAPK events GRB2 events in EGFR signaling SHC1 events in EGFR signaling Downstream signal transduction GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling Tie2 Signaling EGFR Transactivation by Gastrin DAP12 signaling SHC-related events triggered by IGF1R FCERI mediated MAPK activation NCAM signaling for neurite out-growth EPHB-mediated forward signaling Ras activation upon Ca2+ influx through NMDA receptor VEGFR2 mediated cell proliferation CD209 (DC-SIGN) signaling Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 FRS-mediated FGFR1 signaling SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease Regulation of RAS by GAPs RAF activation RAF/MAP kinase cascade MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions RAS signaling downstream of NF1 loss-of-function variants Paradoxical activation of RAF signaling by kinase inactive BRAF Insulin receptor signalling cascade PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAS signaling Activated NTRK2 signals through RAS Erythropoietin activates RAS Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK3 signals through RAS FLT3 Signaling Constitutive Signaling by Overexpressed ERBB2 Estrogen-stimulated signaling through PRKCZ RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by RAS GAP mutants Signaling by RAS GTPase mutants
Drugs		Hexane-1,6-Diol Trifluoroethanol Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE Ursolic acid
Diseases		Penile cancer Cervical cancer Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Hepatocellular carcinoma Thyroid cancer Squamous cell carcinoma Bladder cancer
GWAS			Acute lymphoblastic leukemia (childhood) ( 29348612) Asthma ( 28461288 31959851 31619474) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Asthma with severe exacerbations ( 32841424) Atopic march ( 26542096) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 21102463 28067908) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 29403010 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Multiple sclerosis ( 24076602 31604244) Neutrophil percentage of granulocytes ( 27863252) Pediatric autoimmune diseases ( 26301688) Polycystic ovary syndrome ( 30343302) Primary biliary cholangitis ( 20639880 23000144 30643196 28062665 19458352 26394269) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 23143596 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 27399966 26502338) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908 21297633 20228799)
Interacting Genes		155 interacting genes: ABR ACTG1 AFDN AGTR1 ANAPC1 ANKRD11 ANKRD16 ANKRD23 ANKRD34B APBB1IP ARAF ARFGAP1 ARHGAP10 ARHGAP29 ARHGEF1 ARHGEF18 BCL2 BLID BMPR1A BRAF BRAP BUB1 C6orf62 CAV1 CCL4 CDC123 CDC25A CDC25C CDH1 CDKN2A CTNNA1 CXCL1 DEAF1 DGKE DGKZ DPP9 EIF3L ERBB2 FBXW7 FNTA FNTB FYN GPSM2 GPSM3 GRB2 GREB1 GRIN1 GRIN2D HBG1 HECTD1 HSPA12A HSPA1L ICMT IGF2 IKZF3 IL1RL1 IL24 IL3 INS INSR IRAK1 IRAK2 ITGB3 ITSN1 KCNQ1 KRAS KRT17 KRT18 LGALS1 LZTR1 MAP2K1 MAP2K6 MAP3K6 MAPK10 MAPK8 MLH3 MSH2 MSH6 MTOR MUTYH NEDD4 NF1 NRAS PDE4D PDE6D PDGFB PDGFRL PI4K2A PIK3CA PIK3CD PIK3CG PIK3R1 PLA2G4B PLAAT4 PLCE1 PLCH2 PRKCI PRKCZ PRSS50 PTPRJ QPCT RAB5C RABAC1 RABGEF1 RAF1 RALGDS RAP1B RAP1GDS1 RAPGEF1 RASA1 RASA2 RASA4 RASGRF1 RASGRP1 RASGRP4 RASIP1 RASSF1 RASSF2 RASSF5 RGL1 RGL2 RGL4 RGS12 RHOD RIN1 RIT2 RNF115 RSPO3 SHOC2 SMAD4 SNRPE SNX14 SNX17 SOS1 SOS2 SRC STK11 STK38 TIAM1 TLR2 TLR6 TLR9 TP73 TTC1 TTC21A TTC28 UBE3B UBE4B USP29 USP42 VAV1 ZBTB10 ZBTB12 ZDHHC9 ZFP36L2	166 interacting genes: ABLIM3 AIRIM AKAP10 AKAP9 ANKS1A AQP1 ARMC7 ARNT2 ATP6V0D1 ATP6V0D2 ATPAF2 ATXN7L2 BCAS2 BCL2L1 BLK BLZF1 BYSL C1QL1 CABP4 CABP5 CARD9 CATSPER1 CATSPERT CCDC102B CCDC187 CCDC24 CCDC57 CCHCR1 CDC37 CDC7 CDK4 CDKN1A CDKN2D CFAP206 CHCHD2 CHD3 CKS1B CLCNKA COA3 CRBN CRK CRYBA4 DGCR6 DTX2 EFHC1 EGLN3 EMC2 ENKD1 EXOC8 EXOSC5 FAM124B FANCG FANCL FARS2 FBF1 FHL3 FRS3 GEM GOLGA2 GOLGA6A GRAP2 GRB2 HNRNPF HNRNPLL HOXC8 HRAS IKZF1 IKZF4 IKZF5 ING5 KANK2 KAT5 KIF9 KIFC3 KLHL38 KRT19 LDOC1 LENG1 LGALS14 LMO1 LMO2 LMO4 LNX1 LONRF1 MAD2L2 MAGOHB MCM7 MCRS1 MID2 MISP MKRN3 MORN3 MRPL28 MRPL53 MYO15B NATD1 NBR2 NEK6 NFKBID NME7 NOS3 NTAQ1 NUDT16L1 NXT2 OAZ3 OSBPL7 OSGIN1 PCID2 PDZD4 PFDN5 PIK3R1 PIK3R2 PIN1 POLM POLR1C PPP1R16B PPP1R18 PRAC1 PRDM1 PRKAA1 PRKAA2 PRKAB2 PSMA1 PSME3 PSMF1 RAD51D RBBP8 RCOR3 RHOA RNF6 RUNX1 SCNM1 SMARCB1 SMARCD1 SPG21 STAMBPL1 STK16 STK26 STX11 SUMO1 TBC1D22B TCAF1 TCAP TCEANC TCHP TEKT3 TEKT4 TFAP2D TLE5 TOB1 TRAPPC6A TRIM42 TSEN15 TSGA10IP TSSK3 TSTD2 TUBG2 UBE2I USP2 VAT1 VBP1 YES1 ZGPAT ZMYM2 ZNF587 ZNF76
Entrez ID		3265	22806
HPRD ID		01813	05869
Ensembl ID		ENSG00000174775	ENSG00000161405
Uniprot IDs		P01112 X5D945	Q9UKT9
PDB IDs		121P 1AA9 1AGP 1BKD 1CLU 1CRP 1CRQ 1CRR 1CTQ 1GNP 1GNQ 1GNR 1HE8 1IAQ 1IOZ 1JAH 1JAI 1K8R 1LF0 1LF5 1LFD 1NVU 1NVV 1NVW 1NVX 1P2S 1P2T 1P2U 1P2V 1PLJ 1PLK 1PLL 1Q21 1QRA 1RVD 1WQ1 1XCM 1XD2 1XJ0 1ZVQ 1ZW6 221P 2C5L 2CE2 2CL0 2CL6 2CL7 2CLC 2CLD 2EVW 2LCF 2LWI 2N42 2N46 2Q21 2QUZ 2RGA 2RGB 2RGC 2RGD 2RGE 2RGG 2UZI 2VH5 2X1V 3DDC 3I3S 3K8Y 3K9L 3K9N 3KKM 3KKN 3KUD 3L8Y 3L8Z 3LBH 3LBI 3LBN 3LO5 3OIU 3OIV 3OIW 3RRY 3RRZ 3RS0 3RS2 3RS3 3RS4 3RS5 3RS7 3RSL 3RSO 3TGP 421P 4DLR 4DLS 4DLT 4DLU 4DLV 4DLW 4DLX 4DLY 4DLZ 4DST 4DSU 4EFL 4EFM 4EFN 4G0N 4G3X 4K81 4L9S 4L9W 4NYI 4NYJ 4NYM 4Q21 4RSG 4URU 4URV 4URW 4URX 4URY 4URZ 4US0 4US1 4US2 4XVQ 4XVR 521P 5B2Z 5B30 5E95 5P21 5VBE 5VBZ 5WDO 5WDP 5WDQ 5WFO 5WFP 5WFQ 5WFR 5WPL 5X9S 5ZC6 621P 6AMB 6AXG 6BVI 6BVJ 6BVK 6BVL 6BVM 6CUO 6CUP 6CUR 6D55 6D56 6D59 6D5E 6D5G 6D5H 6D5J 6D5L 6D5M 6D5V 6D5W 6DZH 6E6C 6E6P 6MQT 6NTC 6NTD 6Q21 6V94 6V9F 6V9J 6V9L 6V9M 6V9N 6V9O 6ZJ0 6ZL3 721P 7DPH 7DPJ 7JHP 7JIF 7JIG 7JIH 7JII 7L0F 7L0G 7OG9 7OGA 7OGB 7OGC 7OGD 7OGE 7OGF 7TAM 7VV8 7VV9 7VVG 821P 8BE6 8BE7 8BE8 8BE9 8BEA 8BOS 8BWG 8CNJ 8CNN 8ELK 8ELR 8ELS 8ELT 8ELU 8ELV 8ELW 8ELX 8ELY 8ELZ 8EM0 8FG3 8FG4 8OSM 8OSN 8OSO 8TBG 8TLR 8WWC
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Cytosol Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway MAPK Cascade Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-activating Signaling Pathway Cytoplasm Positive Regulation Of MAPK Cascade Regulation Of Cell Activation Leukocyte Activation Regulation Of Cellular Component Organization Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Protein Kinase Activity Regulation Of Programmed Cell Death Activation Of Immune Response Cellular Response To Oxygen-containing Compound Positive Regulation Of Immune Response Regulation Of Ras Protein Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Defense Response Plasma Membrane Lymphocyte Activation	Protein Binding Nucleus Centrosome Microtubule-based Process Organelle Organization Cytoplasm Nucleoplasm Phosphotyrosine Residue Binding Cis-Golgi Network AMP-activated Protein Kinase Activity Microtubule Cytoskeleton Organization Lipid Droplet Disassembly Sperm Flagellum Microtubule Cytoskeleton Organization Involved In Mitosis Cytoskeleton Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Plasma Membrane Proton-transporting V-type ATPase Complex Axonemal A Tubule Inner Sheath Phosphatidylethanolamine Biosynthetic Process Protein K6-linked Ubiquitination Positive Regulation Of Lymphocyte Activation Regulation Of Mitotic Cell Cycle Nucleotide-activated Protein Kinase Complex Ephrin Receptor Binding Spindle Organization Microtubule Nucleation Cytoskeleton Organization Motile Cilium Regulation Of Autophagy Cyclin D2-CDK4 Complex Axonemal Microtubule Mitotic Spindle Organization Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Cell Activation Regulation Of Lymphocyte Activation Hepatocyte Apoptotic Process Protein Localization To Lipid Droplet Organelle Assembly Regulation Of Cell Cycle
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