HPS1 and HPS4

Number of citations of the paper that reports this interaction (PubMedID 12756248)
0

Data Source:
HPRD (in vivo)

		HPS1	HPS4
Description		HPS1 biogenesis of lysosomal organelles complex 3 subunit 1	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol BLOC-3 Complex Cytoplasmic Vesicle	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane BLOC-3 Complex Cytoplasmic Vesicle Melanosome Platelet Dense Granule
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Dimerization Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity Protein Dimerization Activity
	Biological Process	Lysosome Organization Visual Perception Vesicle-mediated Transport Platelet Dense Granule Organization Melanosome Assembly	Protein Targeting Lysosome Organization Blood Coagulation Hemostasis Vesicle-mediated Transport Melanocyte Differentiation Positive Regulation Of Eye Pigmentation Protein Stabilization Platelet Dense Granule Organization Melanosome Assembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		RAB GEFs exchange GTP for GDP on RABs	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Hermansky-Pudlak syndrome (HPS)	Hermansky-Pudlak syndrome (HPS)
GWAS		Bitter non-alcoholic beverage consumption ( 31046077) Metabolite levels ( 23823483) Obesity-related traits ( 23251661)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Ischemic stroke ( 26089329)
Interacting Genes		2 interacting genes: HPS4 PSEN2	3 interacting genes: DSCR9 HPS1 RAC1
Entrez ID		3257	89781
HPRD ID		05403	05983
Ensembl ID		ENSG00000107521	ENSG00000100099
Uniprot IDs		A0A0S2Z3U9 A0A8V8TMQ9 A0A8V8TN94 H0Y4K4 Q92902	A0A8V8TMY3 A0A8V8TN06 A0A8V8TPB3 A8K2E6 F1LLU8 Q6P1K3 Q9NQG7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Eye Pigmentation Platelet Dense Granule Positive Regulation Of Eye Pigmentation BLOC-3 Complex Mitochondrion-endoplasmic Reticulum Membrane Tethering Gamma-secretase Complex Regulation Of Calcium Import Into The Mitochondrion Aspartic Endopeptidase Activity, Intramembrane Cleaving Positive Regulation Of Developmental Pigmentation Notch Receptor Processing Amyloid-beta Formation Regulation Of Developmental Pigmentation Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Amyloid Precursor Protein Catabolic Process Melanocyte Differentiation Pigment Cell Differentiation Platelet Dense Granule Organization Melanosome Assembly Membrane Protein Proteolysis Melanosome Organization Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Pigment Granule Organization Regulation Of Protein Targeting To Mitochondrion Nuclear Inner Membrane Synaptic Membrane Lysosome Organization Secretory Granule Organization Organelle Localization By Membrane Tethering Membrane Docking Coagulation Melanosome Blood Coagulation Notch Signaling Pathway Hemostasis Synaptic Vesicle Presynaptic Membrane Regulation Of Calcium Ion Transmembrane Transport	BLOC-3 Complex Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Kinocilium Regulation Of Ovarian Follicle Development G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Auditory Receptor Cell Morphogenesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Erythrocyte Enucleation Hepatocyte Growth Factor Receptor Signaling Pathway Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Interleukin-23 Production Regulation Of Neuron Maturation Thioesterase Binding Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Negative Regulation Of Fibroblast Migration Midbrain Dopaminergic Neuron Differentiation Ruffle Assembly Platelet Dense Granule Organization Melanosome Assembly Regulation Of Hydrogen Peroxide Metabolic Process Angiotensin-activated Signaling Pathway Rac Protein Signal Transduction Hyperosmotic Response Respiratory Burst Cochlea Morphogenesis NADPH Oxidase Complex Regulation Of Ruffle Assembly Dopaminergic Neuron Differentiation Sphingosine-1-phosphate Receptor Signaling Pathway Positive Regulation Of Neutrophil Migration Sphingolipid Mediated Signaling Pathway Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lamellipodium Assembly Cerebral Cortex Cell Migration Positive Regulation Of Ruffle Assembly Phagocytic Cup Regulation Of Cell Maturation Interneuron Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Rho Protein Signal Transduction
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