HP and MVP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HP	MVP
Description		haptoglobin	major vault protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen	Extracellular Region Nucleus Nuclear Pore Cytoplasm Cytosol Cytoskeleton Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Protein Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Immune System Process Defense Response Acute-phase Response Inflammatory Response Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process	Cell Population Proliferation Protein Transport Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity Protein Activation Cascade
Pathways		Scavenging of heme from plasma Neutrophil degranulation	Neutrophil degranulation
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Cholesterol, total ( 20686565 25961943) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol ( 20686565 25961943) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010 33339817) Urinary haptoglobin levels in type 2 diabetes ( 29572449)	Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		21 interacting genes: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB HSP90AA1 ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	70 interacting genes: ADAMTSL4 BANP C1orf94 CALCOCO2 CAMK2B CKAP4 DISC1 DLX2 DNAH5 DTX2 EPHX2 ESR1 FMR1 FNDC3B FXR1 FXR2 GIT2 GOLGA2 HP HSPA13 IHO1 KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MRTFA MT-CYB NNT NOTCH2NLA NRF1 NTAQ1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF10 RNF111 SAXO1 SERTAD1 SKIL SLC2A4 STN1 TCF4 TENT5C TFCP2 TLE5 TOLLIP TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 TSPOAP1 UBC UBTD2 VAC14 ZBTB32 ZMIZ2
Entrez ID		3240	9961
HPRD ID		00772	05475
Ensembl ID		ENSG00000257017	ENSG00000013364
Uniprot IDs		A0A0C4DGL8 P00738 Q6PEJ8	Q14764 X5D2M8 X5D7K9 X5DNU0
PDB IDs		4WJG 4X0L 5HU6 6TB2 8XMP 8XMQ 8XMW 9FHB 9FMU	1Y7X 9BW5 9BW6 9BW7 9MXH 9MXV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Integrin AlphaM-beta2 Complex Protein Phosphatase Binding Positive Regulation Of Neutrophil Degranulation Extracellular Exosome Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neutrophil Degranulation Positive Regulation Of Reactive Oxygen Species Metabolic Process Complement Component C3b Binding Regulation Of Immune Response Protein Kinase Binding Protein Stabilization Protein Metabolic Process Endocytic Vesicle Lumen Response To Other Organism Regulation Of Dopamine Metabolic Process Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Response To Stress Ficolin-1-rich Granule Lumen Cargo Receptor Activity Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Leukocyte Activation Integrin Complex Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Establishment Of Protein Localization Microglial Cell Activation Regulation Of Superoxide Metabolic Process Phagocytosis, Engulfment Response To External Biotic Stimulus Regulation Of Protein Targeting To Membrane Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Defense Response Endodermal Cell Differentiation Receptor-mediated Endocytosis Response To Cocaine	Identical Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Biosynthetic Process Cytoplasm Regulation Of Neurogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity PML Body Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nervous System Development Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Translation Regulator Activity Regulation Of Neuronal Synaptic Plasticity TFIIB-class Transcription Factor Binding Viral Penetration Into Host Nucleus Negative Regulation Of Telomere Maintenance Via Telomerase Benzodiazepine Receptor Binding Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Strand Annealing Activity Regulation Of MiRNA-mediated Gene Silencing Somite Specification Dentate Gyrus Development Single-stranded Telomeric DNA Binding MRNA 3'-UTR Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of Viral Process Protein Binding Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Chromosome Organization Positive Regulation Of Neurogenesis Intracellular Membraneless Organelle Presynapse Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Catabolic Process
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