APBB1 and DIAPH2

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		APBB1	DIAPH2
Description		amyloid beta precursor protein binding family B member 1	diaphanous related formin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Nuclear Speck Lamellipodium Growth Cone Cell Projection Synapse	Nucleolus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Cytosol Actin Filament
	Molecular Function	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Low-density Lipoprotein Particle Receptor Binding Molecular Adaptor Activity Proline-rich Region Binding	Actin Binding Signaling Receptor Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Smooth Muscle Contraction DNA Damage Response Signal Transduction Axonogenesis Positive Regulation Of Neuron Projection Development Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion Negative Regulation Of Cell Cycle G1/S Phase Transition	Female Gamete Generation Actin Cytoskeleton Organization Actin Filament Polymerization Cell Differentiation Oogenesis
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	RHOF GTPase cycle
Drugs
Diseases
GWAS		Malaria ( 31844061)
Interacting Genes		73 interacting genes: ABI1 ABL1 ALK ANXA1 APLP1 APLP2 APP ATM ATR ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRKAR2A PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNCA TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1	6 interacting genes: APBB1 CDC42 CENPA NCKIPSD RHOD TCERG1
Entrez ID		322	1730
HPRD ID		04087	02117
Ensembl ID		ENSG00000166313	ENSG00000147202
Uniprot IDs		B7Z4M9 O00213	O60879
PDB IDs		2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing Nucleic Acid Binding RNA Metabolic Process RNA Binding Spliceosomal Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Actin Polymerization Or Depolymerization Nucleus Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Nuclear Speck Protein-RNA Complex Assembly SH3 Domain Binding MRNA Binding Catalytic Step 2 Spliceosome Protein-containing Complex Organization U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Cellular Component Assembly Regulation Of Primary Metabolic Process Nucleoplasm MRNA 3'-splice Site Recognition Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Actin Filament Organization Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Actin Binding Alternative MRNA Splicing, Via Spliceosome Profilin Binding Negative Regulation Of Metabolic Process Regulation Of RNA Splicing SCAR Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Lamellipodium Regulation Of Macromolecule Biosynthetic Process	Positive Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neuron Projection Development Cell Projection Morphogenesis Transcription Coactivator Activity Neuron Projection Morphogenesis Cell Projection Organization Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Thioesterase Binding Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process GTPase Activity Golgi Localization Regulation Of Postsynapse Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Actin Filament Organization Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cell Junction Assembly Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Establishment Of Organelle Localization Neuropilin Signaling Pathway Postsynapse Regulation Of Synapse Organization GBD Domain Binding Golgi Transport Complex Storage Vacuole Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Cell-substrate Adhesion CENP-A Containing Chromatin CENP-A Containing Chromatin Assembly Kinetochore Assembly Transcription Elongation Factor Activity Ubiquitin-like Protein Conjugating Enzyme Binding Regulation Of Cell Junction Assembly Arp2/3 Complex Binding Regulation Of Cellular Component Organization Proline-rich Region Binding Cell Projection Regulation Of Actin Cytoskeleton Organization Cell Projection Assembly Cardiac Conduction System Development
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