HOXA3 and RCHY1

Number of citations of the paper that reports this interaction (PubMedID 26496426)
52

Data Source:
BioGRID (protein complementation assay)

		HOXA3	RCHY1
Description		homeobox A3	ring finger and CHY zinc finger domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding HMG Box Domain Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Angiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Specification Of Animal Organ Position Gene Expression Glossopharyngeal Nerve Morphogenesis Thyroid Gland Development Thymus Development Animal Organ Formation Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Cartilage Development Parathyroid Gland Development Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		A body shape index ( 34021172) Chronic venous disease ( 28374850) Diastolic blood pressure ( 27618448) Hypertension ( 27618448 30487518) Lymphocyte count ( 32888494) Mean arterial pressure ( 27618448) Monocyte count ( 27863252 32888494) Pulse pressure ( 30487518) Systolic blood pressure ( 30487518 28135244 27618448) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Interacting Genes		10 interacting genes: ALX4 ARPC3 POT1 PWP1 RCHY1 SEC23B SOX10 TERF1 TINF2 ZDHHC17	74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160
Entrez ID		3200	25898
HPRD ID		00842	07607
Ensembl ID		ENSG00000105997	ENSG00000163743
Uniprot IDs		A4D182 B3KPN8 O43365	Q96PM5
PDB IDs			2JRJ 2K2C 2K2D 7YNX
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere DNA Metabolic Process Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of DNA Metabolic Process Chromosome Positive Regulation Of Shelterin Complex Assembly Growth Cone Leading Edge Histone H4K20me3 Reader Activity Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Macromolecule Biosynthetic Process Chromosome Organization Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis
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