APAF1 and NUDT4

		APAF1	NUDT4
Description		apoptotic peptidase activating factor 1	nudix hydrolase 4
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding Cysteine-type Endopeptidase Activator Activity	Endopolyphosphatase Activity RNA Binding Protein Binding Diphosphoinositol-polyphosphate Diphosphatase Activity Pyrophosphatase Activity Hydrolase Activity SnoRNA Binding Bis(5'-adenosyl)-hexaphosphatase Activity Bis(5'-adenosyl)-pentaphosphatase Activity Metal Ion Binding Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol-5-diphosphate-1,3,4,6-tetrakisphosphate Diphosphatase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
	Biological Process	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Nervous System Development Brain Development Response To Nutrient Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process System Development Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway	Calcium-mediated Signaling Intracellular Signal Transduction Diphosphoinositol Polyphosphate Metabolic Process Diadenosine Pentaphosphate Catabolic Process Diadenosine Hexaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity	Synthesis of pyrophosphates in the cytosol
Drugs		ATP
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)	Immature fraction of reticulocytes ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		31 interacting genes: ACADS APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CCL13 CDK17 CYCS DZIP1 ELK3 FAS FEM1B HIP1 HNF1A HSP90AA1 HSPA1A MRPL19 NLRP1 NR1H4 NUDT4 NUP107 PAH PPP1CA RPL26L1 TOP1 TRIAP1 UTP20	2 interacting genes: APAF1 KEAP1
Entrez ID		317	11163
HPRD ID		03755	14850
Ensembl ID		ENSG00000120868	ENSG00000173598
Uniprot IDs		O14727	A0A024RBG1 A0A0C4DGJ4 Q9NZJ9
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE 8XQK	5LTU 7NNJ
Enriched GO Terms of Interacting Partners?		Cell Death Programmed Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Response To Anesthetic Death-inducing Signaling Complex Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion Mitochondrion Leukocyte Apoptotic Process Neuron Apoptotic Process Positive Regulation Of Apoptotic Process Death Receptor Binding Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Nucleus Positive Regulation Of Neuron Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptosome Response To Radiation Execution Phase Of Apoptosis Positive Regulation Of Defense Response Negative Regulation Of Programmed Cell Death Response To Stress Glial Cell Apoptotic Process Cytosol Inflammatory Response CD95 Death-inducing Signaling Complex NLRP1 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Regulation Of Neuron Apoptotic Process Cysteine-type Peptidase Activity Negative Regulation Of Apoptotic Process Self Proteolysis Response To UV Fibroblast Apoptotic Process Intracellular Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Maturation Cellular Response To Radiation Positive Regulation Of Inflammatory Response Response To Light Stimulus Interleukin-18-mediated Signaling Pathway	Response To G1 DNA Damage Checkpoint Signaling Regulation Of Apoptotic DNA Fragmentation Apoptosome Response To DNA Damage Checkpoint Signaling Cysteine-type Endopeptidase Activator Activity Negative Regulation Of Response To Oxidative Stress Cardiac Muscle Cell Apoptotic Process Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Striated Muscle Cell Apoptotic Process Protein-containing Complex Muscle Cell Apoptotic Process Inclusion Body Cellular Response To Interleukin-4 Disordered Domain Specific Binding Response To Interleukin-4 Regulation Of Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress ADP Binding Transcription Regulator Inhibitor Activity
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