HMGB1 and CRMP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HMGB1	CRMP1
Description		high mobility group box 1	collapsin response mediator protein 1
Image
GO Annotations	Cellular Component	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Cell Surface Membrane Transcription Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Neuron Projection Ficolin-1-rich Granule Lumen	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Actin Cytoskeleton Dendrite Growth Cone Midbody Cell Projection Neuronal Cell Body Perikaryon Presynapse Postsynapse
	Molecular Function	Four-way Junction DNA Binding Bubble DNA Binding Transcription Cis-regulatory Region Binding Lipopolysaccharide Binding Phosphatidylserine Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Cytokine Activity Integrin Binding Protein Binding Lipid Binding DNA Binding, Bending Calcium-dependent Protein Kinase Regulator Activity Lyase Activity C-X-C Chemokine Binding Protein Kinase Activator Activity Chemoattractant Activity Receptor Ligand Activity RAGE Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Polymerase Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Filamin Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Myeloid Dendritic Cell Activation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Activation Of Innate Immune Response Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Macrophage Activation Involved In Immune Response Myeloid Progenitor Cell Differentiation Immune System Process Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell Glycogen Catabolic Process DNA Metabolic Process DNA Topological Change DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Chromatin Remodeling Transcription By RNA Polymerase II Autophagy Chemotaxis Inflammatory Response Immune Response DNA Damage Response Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Myeloid Cell Differentiation Lung Development Neuron Projection Development Heterochromatin Formation Regulation Of Restriction Endodeoxyribonuclease Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Endothelial Cell Chemotaxis Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Viral Entry Into Host Cell Cell Development Regulation Of Viral Process Positive Chemotaxis Regulation Of DNA Metabolic Process Response To Glucocorticoid Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Wound Healing Neutrophil Clearance Cellular Response To Interleukin-7 Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Sprouting Angiogenesis Regulation Of Hemopoiesis Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleotide-excision Repair Positive Regulation Of Dendritic Cell Differentiation	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly
Pathways		ER-Phagosome pathway Apoptosis induced DNA fragmentation MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAK1-dependent IKK and NF-kappa-B activation MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	CRMPs in Sema3A signaling
Drugs		Chloroquine Ethyl pyruvate
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30297969) Urate levels ( 31578528)	Blood trace element (Zn levels) ( 23720494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		134 interacting genes: ACBD3 AGER AGTRAP AKIP1 ALK AR ATF7IP ATOH1 C1QA C1QBP C3 CASP3 CCAR1 CCNDBP1 CDK1 CEBPA CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DAG1 DLAT DNAAF2 DNM2 DNMT1 DUX4 DYNC2I1 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FLT1 FOS FOXA3 FOXC1 GOLM1 GTF2A1 HDAC1 HDLBP HES1 HMGA1 HNRNPK HNRNPU HOXA10 HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MALAT1 MAP1B MAPKAPK5 MECP2 MIEN1 MNAT1 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PSMA7 PTPN2 PTPRZ1 RAD23B RAG1 RASAL2 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 RSF1 SIX5 SOX18 SPIN1 SPINT1 SRSF3 STUB1 TAF1 TAF3 TBP TERF2 TERF2IP TFE3 TGIF1 TGM2 TGM3 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBC UBE2E3 UBE2I UBXN1 UHRF2 UNC119 USP12 WNK4 YY1 ZFP36 ZNF24 ZNF428	81 interacting genes: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DISC1 DNAJB11 DPYSL2 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LRRK2 LSM2 MAP3K20 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RACK1 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RSPH1 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1 ZNF24
Entrez ID		3146	1400
HPRD ID		01228	03913
Ensembl ID		ENSG00000189403	ENSG00000072832
Uniprot IDs		B7Z965 P09429 Q5T7C4	B3KT07 B3KV96 E9PD68 Q14194 Q96I11 X5DNI1
PDB IDs		2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM 6OEM 6OEN 6OEO 8I9M	4B3Z
Enriched GO Terms of Interacting Partners?		Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regionalization Anterior/posterior Pattern Specification Transcription Cis-regulatory Region Binding Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Pattern Specification Process Positive Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Binding Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis	Cytoplasm Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytosol Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding RNA Binding Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Protein Binding Protein-containing Complex Organization Organelle Organization Regulation Of Signal Transduction Cytoskeleton Organization Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Membrane Potential Cellular Component Assembly Nucleus Regulation Of Programmed Cell Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Regulation Of MAPK Cascade Protein-containing Complex Assembly Regulation Of Apoptotic Process Perinuclear Region Of Cytoplasm BAT3 Complex Binding Regulation Of Wnt Signaling Pathway Regulation Of Mitochondrial Depolarization Catabolic Process Positive Regulation Of Autophagy Regulation Of Cellular Response To Stress Regulation Of Protein Metabolic Process Regulation Of CAMKK-AMPK Signaling Cascade Negative Regulation Of Hippo Signaling HULC Complex Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Branching Morphogenesis Of A Nerve Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Microtubule Cytoskeleton Organization
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