HLA-F and LILRB2

Number of citations of the paper that reports this interaction (PubMedID 11169396)
0

Data Source:
HPRD (in vitro, in vivo)

		HLA-F	LILRB2
Description		major histocompatibility complex, class I, F	leukocyte immunoglobulin like receptor B2
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class Ib Protein Complex MHC Class I Protein Complex Recycling Endosome Membrane Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Space Cytoplasm Plasma Membrane Cell Surface Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding TAP1 Binding TAP2 Binding 14-3-3 Protein Binding	Amyloid-beta Binding Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Complex Binding MHC Class Ib Protein Binding Inhibitory MHC Class I Receptor Activity MHC Class I Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Negative Regulation Of T Cell Cytokine Production Negative Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Negative Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity	Adaptive Immune Response Immune System Process Negative Regulation Of Antigen Processing And Presentation Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Immune Response-regulating Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Learning Or Memory Positive Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Interleukin-10-mediated Signaling Pathway Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Depression Negative Regulation Of Postsynaptic Density Organization Negative Regulation Of T Cell Costimulation Regulation Of Dendritic Cell Differentiation
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22412388) Hip circumference adjusted for BMI ( 34021172) Lung cancer ( 31577861) Mixed cellularity Hodgkin lymphoma ( 29196614) Nasopharyngeal carcinoma ( 19664746) Offspring birth weight ( 31043758)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) HDL cholesterol ( 20686565) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lactate dehydrogenase levels ( 29403010) Nonsyndromic cleft lip ( 31609978)
Interacting Genes		5 interacting genes: B2M CHRM5 LILRB1 LILRB2 TAP1	8 interacting genes: FCGR1A FDX1 HLA-A HLA-B HLA-C HLA-F HLA-G PTPN6
Entrez ID		3134	10288
HPRD ID		00884	11994
Ensembl ID		ENSG00000204642	ENSG00000131042
Uniprot IDs		A0A0G2JH66 D0EV57 P30511 Q5JZ47 Q5JZ48	Q8N423
PDB IDs		5IUE 5KNM	2DYP 2GW5 4LLA 6AED 6BCS
Enriched GO Terms of Interacting Partners?		MHC Class Ib Protein Binding MHC Class I Protein Binding MHC Class Ib Protein Complex Binding Adaptive Immune Response Fc Receptor Mediated Inhibitory Signaling Pathway Inhibitory MHC Class I Receptor Activity MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Monoatomic Ion Transport Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Interleukin-10-mediated Signaling Pathway Immune Response-inhibiting Signal Transduction Regulation Of Dendritic Cell Differentiation Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Protein Homodimerization Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Phosphatase 1 Binding Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of T Cell Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Positive Regulation Of Leukocyte Cell-cell Adhesion Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Metal Ion Transport Negative Regulation Of Calcium Ion Transport Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Regulation Of Hemopoiesis Negative Regulation Of Endocytosis Defense Response Cellular Response To Lipid Negative Regulation Of T Cell Proliferation Phagocytic Vesicle Membrane Positive Regulation Of Cytokine Production Positive Regulation Of Cell Adhesion Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cell-cell Adhesion Amyloid-beta Binding Regulation Of Lymphocyte Activation Negative Regulation Of Lymphocyte Proliferation	MHC Class I Protein Complex Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Endogenous Antigen Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Positive Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Binding Positive Regulation Of Immune Effector Process Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Regulation Of T Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Cytotoxicity ER To Golgi Transport Vesicle Membrane Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity TAP Binding Early Endosome Membrane Phagocytic Vesicle Membrane Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Leukocyte Mediated Cytotoxicity Negative Regulation Of Innate Immune Response Recycling Endosome Membrane Regulation Of T Cell Mediated Immunity Positive Regulation Of Immune Response Protection From Natural Killer Cell Mediated Cytotoxicity External Side Of Plasma Membrane Regulation Of Defense Response Regulation Of Innate Immune Response Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Negative Regulation Of Defense Response Adaptive Immune Response Lymphocyte Mediated Immunity Regulation Of Cytokine Production Leukocyte Mediated Immunity Signaling Receptor Binding Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Mediated Immunity
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