NRG1 and LIPF

		NRG1	LIPF
Description		neuregulin 1	lipase F, gastric type
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Plasma Membrane Membrane Apical Plasma Membrane Glutamatergic Synapse	Extracellular Region Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coregulator Activity Signaling Receptor Binding Cytokine Activity Integrin Binding Protein Binding Growth Factor Activity Zinc Ion Binding Nickel Cation Binding Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding Chemorepellent Activity Receptor Ligand Activity	Triacylglycerol Lipase Activity Protein Binding Lipid Binding Lipase Activity Malate Dehydrogenase Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Carboxylic Ester Hydrolase Activity
	Biological Process	Ventricular Trabecula Myocardium Morphogenesis Cell Communication Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Brain Development Peripheral Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Communication Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Regulation Of Signaling Cell Differentiation Positive Regulation Of Cell Growth Mammary Gland Development Positive Regulation Of Protein-containing Complex Assembly Activation Of Protein Kinase B Activity Intracellular Signal Transduction ERBB Signaling Pathway ERBB2 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway ERBB4-ERBB4 Signaling Pathway Wound Healing Positive Regulation Of Cell Adhesion Negative Regulation Of DNA-templated Transcription Negative Chemotaxis Negative Regulation Of Secretion Positive Regulation Of Developmental Process Positive Regulation Of Striated Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Malate Metabolic Process Lipid Metabolic Process Triglyceride Metabolic Process Lipid Catabolic Process
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Long-term potentiation Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Digestion of dietary lipid
Drugs			Orlistat Undecyl-Phosphinic Acid Butyl Ester
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Cardiac Troponin-T levels ( 23247143) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronotype ( 30696823) Cognitive function ( 25644384) Coronary artery calcification ( 23870195) Dialysis-related mortality ( 21546767) Differentiated thyroid cancer ( 28703219) Diffusing capacity of carbon monoxide ( 30694715) Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 30604766) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip geometry ( 17903296) Hirschsprung disease ( 19196962 27702942 25310821) Hypothyroidism ( 27182965) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Major depressive disorder ( 29317602) Malaria ( 31844061) Metabolite levels (X-11787) ( 23934736) Morning person ( 30696823) Non-small cell lung cancer ( 31326317) Obstructive sleep apnea ( 25325441) Papillary thyroid cancer ( 28703219) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Refractive astigmatism ( 25367360) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Rheumatic heart disease ( 34106200) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Urate levels ( 31578528) Weight ( 28552196)	Estimated glomerular filtration rate in coronary artery disease and impaired kidney function ( 30809046) Intake of total sugars ( 31005972)
Interacting Genes		23 interacting genes: ADAM19 ADGRA2 ASGR2 CD72 CEBPD DKK4 EGF EGFR EIF4EBP1 ERBB2 ERBB3 ERBB4 FGFR1 IKZF4 ISG20 JAGN1 KCNK4 LAPTM4B LIMK1 LIPF MS4A4A PLP1 TMEM54	5 interacting genes: CLPS MEOX2 NRG1 PSEN2 PTEN
Entrez ID		3084	8513
HPRD ID		00802	09063
Ensembl ID		ENSG00000157168	ENSG00000182333
Uniprot IDs		A0A024QY88 A0A494C0K4 A0A494C0L9 A0A494C0Q4 A0A494C114 A0A494C1B5 A0A494C1F5 A0A494C1F8 A5YAK6 A5YAK8 A6MW54 A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 E3SFM9 E5RHP6 Q02297 Q6PK61 Q7RTW3 Q7RTW5	P07098
PDB IDs		1HAE 1HAF 1HRE 1HRF 3U7U 7MN5 7MN6 7MN8 7SJL 8U4I 8U4L	1HLG
Enriched GO Terms of Interacting Partners?		ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2-EGFR Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Signaling Receptor Activity Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Growth ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Positive Regulation Of Phosphate Metabolic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Salivary Gland Morphogenesis Glial Cell Development Intracellular Signaling Cassette Positive Regulation Of Protein Modification Process Kinase Activity Regulation Of Protein Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Regulation Of Phosphorylation Mammary Gland Alveolus Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction System Development Basolateral Plasma Membrane Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Myelination Axon Ensheathment	Lipase Binding Activation Of Protein Kinase B Activity Ventricular Cardiac Muscle Cell Differentiation ErbB-3 Class Receptor Binding Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Organ Growth Positive Regulation Of Protein Autophosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway Endocardial Cell Differentiation ERBB4 Signaling Pathway Nickel Cation Binding ERBB4-ERBB4 Signaling Pathway Somite Specification Notch Receptor Processing Mitochondrion-endoplasmic Reticulum Membrane Tethering Gamma-secretase Complex Regulation Of Calcium Import Into The Mitochondrion Aspartic Endopeptidase Activity, Intramembrane Cleaving Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Cell Size Rhythmic Synaptic Transmission Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Presynaptic Membrane Assembly Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Regulation Of Developmental Growth Apical Plasma Membrane Ventricular Trabecula Myocardium Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Protein Tyrosine Kinase Activator Activity Cardioblast Differentiation Regulation Of Protein Autophosphorylation Segment Specification Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?