LIPF

Description		lipase F, gastric type
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GO Annotations	Cellular Component	Extracellular Region Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Triacylglycerol Lipase Activity Protein Binding Lipid Binding Lipase Activity Malate Dehydrogenase Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Carboxylic Ester Hydrolase Activity
	Biological Process	Malate Metabolic Process Lipid Metabolic Process Triglyceride Metabolic Process Lipid Catabolic Process
Pathways		Digestion of dietary lipid
Drugs		Orlistat Undecyl-Phosphinic Acid Butyl Ester
Diseases
GWAS		Estimated glomerular filtration rate in coronary artery disease and impaired kidney function ( 30809046) Intake of total sugars ( 31005972)
Novel Interacting Genes		5 novel interacting genes: CLPS MEOX2 NRG1 PSEN2 PTEN
Interacting Genes		5 interacting genes: CLPS MEOX2 NRG1 PSEN2 PTEN
Entrez ID		8513
HPRD ID		09063
Ensembl ID		ENSG00000182333
Uniprot IDs		P07098
PDB IDs		1HLG
Enriched GO Terms of Interacting Partners?		Lipase Binding Activation Of Protein Kinase B Activity Ventricular Cardiac Muscle Cell Differentiation ErbB-3 Class Receptor Binding Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Organ Growth Positive Regulation Of Protein Autophosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway Endocardial Cell Differentiation ERBB4 Signaling Pathway Nickel Cation Binding ERBB4-ERBB4 Signaling Pathway Somite Specification Notch Receptor Processing Mitochondrion-endoplasmic Reticulum Membrane Tethering Gamma-secretase Complex Regulation Of Calcium Import Into The Mitochondrion Aspartic Endopeptidase Activity, Intramembrane Cleaving Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Cell Size Rhythmic Synaptic Transmission Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Presynaptic Membrane Assembly Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Regulation Of Developmental Growth Apical Plasma Membrane Ventricular Trabecula Myocardium Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Protein Tyrosine Kinase Activator Activity Cardioblast Differentiation Regulation Of Protein Autophosphorylation Segment Specification Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration
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