SOX8 and EGR2

Number of citations of the paper that reports this interaction (PubMedID 16582099)
44

Data Source:
HPRD (in vitro)

		SOX8	EGR2
Description		SRY-box transcription factor 8	early growth response 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Positive Regulation Of Gene Expression Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Neural Crest Cell Development Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Brain Development Peripheral Nervous System Development Rhythmic Behavior Motor Neuron Axon Guidance Gene Expression Schwann Cell Differentiation Positive Regulation Of Schwann Cell Differentiation Protein Sumoylation Rhombomere 3 Development Facial Nerve Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Structural Organization Rhombomere 5 Formation Regulation Of Ossification Positive Regulation Of Myelination Brain Segmentation Aorta Development Skeletal Muscle Cell Differentiation Myelination Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Logical memory (immediate recall) in normal cognition ( 29274321) Multiple sclerosis ( 21833088 31604244) Polycystic ovary syndrome ( 25574032)	Adventurousness ( 30643258) Alopecia areata ( 25608926) Atopic dermatitis ( 23042114) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Ewing sarcoma ( 22327514) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Monocyte percentage of white cells ( 32888494) Selective IgA deficiency ( 27723758) Temperament ( 22832960) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Vogt-Koyanagi-Harada syndrome ( 25108386)
Interacting Genes		18 interacting genes: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1	22 interacting genes: ACP5 BPGM DNMT3L GOLGA2 HCFC1 JPT2 KCTD17 MCRS1 MED31 NAB2 NDUFS2 NFATC1 PDE4DIP RBM15B RIMKLB RPL7L1 SOX10 SOX8 SRA1 UBE2I WEE2-AS1 WWP2
Entrez ID		30812	1959
HPRD ID		16175	00551
Ensembl ID		ENSG00000005513	ENSG00000122877
Uniprot IDs		P57073	A0A8I5KYI5 P11161
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II HMG Box Domain Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Response To Gonadotropin-releasing Hormone Positive Regulation Of Developmental Process Cellular Developmental Process Regulation Of Metabolic Process Developmental Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process System Development CAMP Response Element Binding Nucleus Transcription Regulator Complex Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Host-mediated Activation Of Viral Transcription Positive Regulation Of Canonical Wnt Signaling Pathway Nervous System Development Cell Differentiation Organ Induction Double-stranded DNA Binding	Negative Regulation Of Nucleobase-containing Compound Metabolic Process NSL Complex Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Enteric Nervous System Development Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Glial Cell Differentiation Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Complex Positive Regulation Of RNA Biosynthetic Process MLL1 Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Development Negative Regulation Of Myoblast Differentiation Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Superoxide Anion Generation Positive Regulation Of RNA Metabolic Process SUMO Conjugating Enzyme Activity Citrate-L-glutamate Ligase Activity N-acetyl-L-aspartate-L-glutamate Ligase Activity Oligodendrocyte Differentiation DNA-binding Transcription Factor Binding Regulation Of Gene Expression Centrosome Cycle
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