ANXA3 and UBR1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ANXA3	UBR1
Description		annexin A3	ubiquitin protein ligase E3 component n-recognin 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Vesicle Membrane Membrane Phagocytic Vesicle Membrane Specific Granule Extracellular Exosome	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function	Phosphatidylserine Binding Phospholipase Inhibitor Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Calcium-dependent Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding
	Biological Process	Phagocytosis Positive Regulation Of Endothelial Cell Migration Defense Response To Bacterium Neutrophil Degranulation Positive Regulation Of Angiogenesis Positive Regulation Of DNA-binding Transcription Factor Activity	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		Developmental Lineage of Pancreatic Ductal Cells	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fluocinolone acetonide Ethanolamine Difluocortolone
Diseases			Johanson-Blizzard syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Daytime nap ( 33568662) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metabolite levels ( 23823483) Non-albumin protein levels ( 22558069) Refractive error ( 32231278) Rheumatoid arthritis ( 22446963 30423114)	Appendicular lean mass ( 33097823) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		7 interacting genes: BAG5 EMG1 IGSF21 REG3A TP53 UBR1 UNC119	33 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 COXFA4L2 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PLIN2 PTPRS RGS4 SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2
Entrez ID		306	197131
HPRD ID		00111	09342
Ensembl ID		ENSG00000138772	ENSG00000159459
Uniprot IDs		P12429	Q8IWV7
PDB IDs		1AII 1AXN	3NY1 5TDC
Enriched GO Terms of Interacting Partners?		Response To Symbiotic Bacterium Response To Symbiont Positive Regulation Of Detection Of Glucose Protein-folding Chaperone Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Proteolysis Glial Cell Apoptotic Process Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D ATP-dependent DNA/DNA Annealing Activity Negative Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Protein Refolding Negative Regulation Of Protein Folding RRNA (pseudouridine) Methyltransferase Activity Nucleologenesis Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Negative Regulation Of Cellular Component Organization B Cell Lineage Commitment Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Pentose-phosphate Shunt Junctional Membrane Complex Nucleolus Organization Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Regulation Of Caveolin-mediated Endocytosis L-leucine Binding	Protein-N-terminal Asparagine Amidohydrolase Activity HULC Complex Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
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