HADHB and DDX17

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		HADHB	DDX17
Description		hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	DEAD-box helicase 17
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Nucleoid	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Ribonucleoprotein Complex
	Molecular Function	RNA Binding (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Acetyl-CoA C-acetyltransferase Activity Acetyl-CoA C-acyltransferase Activity Enoyl-CoA Hydratase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein-containing Complex Binding Acetyl-CoA C-myristoyltransferase Activity LncRNA Binding	Nucleotide Binding Nucleic Acid Binding Transcription Coactivator Activity RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Gene Expression Cellular Response To Lipopolysaccharide	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Epithelial To Mesenchymal Transition Immune System Process Regulation Of Transcription By RNA Polymerase II RRNA Processing RNA Processing MRNA Processing RNA Splicing MiRNA Metabolic Process Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Regulatory NcRNA-mediated Gene Silencing Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA	SUMOylation of transcription cofactors
Drugs
Diseases
GWAS			Hip index ( 34021172) Menopause (age at onset) ( 26414677) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		19 interacting genes: ALK ANXA7 APP CDC42 CDKN1A CEBPA CHCHD4 COX17 DDX17 GRB7 HSD17B10 HSPB2 RCC1 SMN1 SUOX TIMM8B TK1 TNNI3K UBC	50 interacting genes: APBB1 APP BYSL CCDC187 CEBPA CREBBP CSNK2A1 DDX5 DDX6 DNAL4 DRC4 EGFR ESR1 FBL FOXP1 FXR2 GRB2 HADHB HDAC1 HNRNPH1 HNRNPH3 HNRNPK LNX1 NCOA1 NCOA2 NCOA3 OGT PIN1 PRPF6 PTK6 PTPRD RBM10 RBM14 RBM15 RBM4 RBM5 RBM7 SF1 SF3B4 SFPQ SNCA SNRNP70 SNRPA SORBS3 SREK1 SUMO2 USP7 WBP11 WBP2 YWHAG
Entrez ID		3032	10521
HPRD ID		00887	10532
Ensembl ID		ENSG00000138029	ENSG00000100201
Uniprot IDs		F5GZQ3 P55084	A0A5H1ZRQ2 Q59F66 Q92841
PDB IDs		5ZQZ 5ZRV 6DV2	6UV0 6UV1 6UV2 6UV3 6UV4
Enriched GO Terms of Interacting Partners?		Mitochondrial Intermembrane Space	Nucleoplasm MRNA Metabolic Process RNA Splicing RNA Binding RNA Metabolic Process Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process Spliceosomal Complex Regulation Of RNA Splicing RNA Processing Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Rhythmic Process Regulation Of MRNA Processing Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II MRNA Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Nuclear Speck Chromatin Remodeling Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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