HAGH and TIMM10

		HAGH	TIMM10
Description		hydroxyacylglutathione hydrolase	translocase of inner mitochondrial membrane 10
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Intermembrane Space Membrane Mitochondrial Intermembrane Space Chaperone Complex TIM22 Mitochondrial Import Inner Membrane Insertion Complex
	Molecular Function	Hydroxyacylglutathione Hydrolase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding Zinc Ion Binding Membrane Insertase Activity Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding
	Biological Process	Glutathione Metabolic Process Glutathione Biosynthetic Process Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione	Protein Targeting To Mitochondrion Sensory Perception Of Sound Protein Transport Protein Insertion Into Mitochondrial Inner Membrane
Pathways			Mitochondrial protein import Mitochondrial protein import Mitochondrial protein degradation
Drugs		Glutathione S-(N-hydroxy-N-bromophenylcarbamoyl)glutathione
Diseases
GWAS			Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		7 interacting genes: APOBEC3A APP BST2 MYOC SHANK3 TERF2IP TIMM10	8 interacting genes: - CNTF CREB3 DAGLA HAGH TBC1D21 TKFC ZNF655
Entrez ID		3029	26519
HPRD ID		00731	03768
Ensembl ID		ENSG00000063854	ENSG00000134809
Uniprot IDs		H3BPQ4 Q16775	P62072
PDB IDs		1QH3 1QH5	2BSK 7CGP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Frizzled Binding Modulation Of Excitatory Postsynaptic Potential Regulation Of Viral Genome Replication Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Negative Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Negative Regulation Of Actin Filament Bundle Assembly Skeletal Muscle Hypertrophy Mitochondrial Intermembrane Space Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Positive Regulation Of Cellular Component Organization Associative Learning Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Membrane Potential Positive Regulation Of JNK Cascade Neuron Projection Development Positive Regulation Of Intracellular Signal Transduction Lipoprotein Particle Mitochondrial Inner Membrane Positive Regulation Of Protein Import Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Dendritic Cell Cytokine Production Regulation Of Organelle Organization Negative Regulation Of DNA Recombination At Telomere Guanylate Kinase-associated Protein Clustering Regulation Of Viral Life Cycle Regulation Of Cellular Component Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import	Aldehyde Metabolic Process Positive Regulation Of Deacetylase Activity Glycerone Kinase Activity Triokinase Activity FAD-AMP Lyase (cyclizing) Activity Retrograde Trans-synaptic Signaling By Endocannabinoid Monoacylglycerol Biosynthetic Process Cannabinoid Biosynthetic Process Diacylglycerol Catabolic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Metabolic Process Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione CCR1 Chemokine Receptor Binding Release From Viral Latency Glycerol Catabolic Process Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Negative Regulation Of MDA-5 Signaling Pathway Sperm Mitochondrial Sheath Assembly Varicosity Muscle Organ Morphogenesis Lipoprotein Lipase Activity Positive Regulation Of Axon Regeneration Retinal Rod Cell Differentiation CAMP Response Element Binding Protein Binding Plasma Membrane To Endosome Transport Monoacylglycerol Lipase Activity Glyceraldehyde-3-phosphate Metabolic Process
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