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H2BC3 and KMT2C
Number of citations of the paper that reports this interaction (PubMedID
36598580
)
84
Data Source:
BioGRID
(pull down)
H2BC3
KMT2C
Description
H2B clustered histone 3
lysine methyltransferase 2C
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Chromosome
Cytosol
Nucleus
Nucleoplasm
Cytosol
Histone Methyltransferase Complex
MLL3/4 Complex
Molecular Function
DNA Binding
Protein Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
DNA Binding
Transcription Coactivator Activity
RNA Binding
Protein Binding
Methyltransferase Activity
Zinc Ion Binding
Transferase Activity
Acyltransferase Activity
Histone Methyltransferase Activity
Histone H3K4 Methyltransferase Activity
Metal Ion Binding
Histone H3K4 Monomethyltransferase Activity
Histone H3K4 Trimethyltransferase Activity
Biological Process
Nucleosome Assembly
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Methylation
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
PKMTs methylate histone lysines
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Formation of WDR5-containing histone-modifying complexes
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
Interacting Genes
49 interacting genes:
AKT1
ANAPC11
APP
BAP1
BARD1
BMI1
BRCA1
CDC20
CDK1
CDK2
CHD4
CREBBP
DNMT1
DYRK1A
EID1
EP300
ERCC6
FANCD2
HUWE1
KAT2A
KAT2B
KMT2A
KMT2C
KMT2D
MYB
PALB2
PIAS1
PSMD4
PTPN6
RHBDD2
RNF168
RNF2
RNF20
RNF40
RNF8
RPS6KA5
SMYD5
TSPYL5
UBE2A
UBR7
UHRF1
USP16
USP2
USP21
USP22
USP36
USP43
USP51
USP7
14 interacting genes:
APPL2
DPY30
H2AC4
H2BC3
H3-4
H3C1
H3C14
H4C1
JUN
MAPK14
MTNR1B
RNF10
SMARCB1
TSC22D1
Entrez ID
3018
58508
HPRD ID
07536
06016
Ensembl ID
ENSG00000276410
ENSG00000055609
Uniprot IDs
P33778
Q8NEZ4
PDB IDs
3X1S
3X1U
9C62
9FGQ
2YSM
2YUK
3UVL
4ERY
5F59
5F6K
6KIW
6MLC
7W6L
Enriched GO Terms of Interacting Partners
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Chromatin Remodeling
Chromatin Organization
Post-translational Protein Modification
Protein Modification Process
Nucleoplasm
Protein Metabolic Process
Macromolecule Metabolic Process
Epigenetic Regulation Of Gene Expression
Protein Deubiquitination
DNA Repair
Chromatin Binding
Protein Modification By Small Protein Removal
DNA Damage Response
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Transferase Activity
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Proteolysis
Nucleus
DNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cell Cycle
Regulation Of Gene Expression
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Response To Radiation
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein Modification By Small Protein Conjugation
Cysteine-type Deubiquitinase Activity
Negative Regulation Of Biosynthetic Process
Protein Ubiquitination
Transcription Coactivator Activity
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Double-strand Break Repair
Regulation Of DNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of DNA-templated Transcription
Structural Constituent Of Chromatin
Nucleosome
Nucleosome Organization
Protein-DNA Complex Assembly
Chromatin Remodeling
Nucleosome Assembly
Chromatin Organization
Protein Heterodimerization Activity
Protein-containing Complex Assembly
Protein-containing Complex Organization
DNA Binding
Chromosome
Negative Regulation Of Cell Population Proliferation
Nucleus
Regulation Of Cell Development
Epigenetic Regulation Of Gene Expression
Regulation Of Cell Differentiation
Host-mediated Activation Of Viral Transcription
CENP-A Containing Nucleosome
Protein Localization To CENP-A Containing Chromatin
Regulation Of Cell Population Proliferation
Response To Muscle Stretch
Cellular Component Assembly
Host-mediated Perturbation Of Viral Transcription
Nuclear Chromosome
Regulation Of Hemopoiesis
Chromosome, Telomeric Region
Host-mediated Activation Of Viral Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Protein Localization To Chromosome, Centromeric Region
Regulation Of Multicellular Organismal Development
Positive Regulation Of Myoblast Differentiation
Regulation Of Gene Expression
Transcription Initiation-coupled Chromatin Remodeling
Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Protein Localization To Chromatin
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Multicellular Organismal Process
Positive Regulation Of Gene Expression, Epigenetic
Regulation Of Macromolecule Biosynthetic Process
Regulation Of D-glucose Import
Nucleoplasm
Negative Regulation Of Cell Development
Regulation Of Developmental Process
Leading Edge Cell Differentiation
Positive Regulation Of Macropinocytosis
Regulation Of D-glucose Transmembrane Transport
Regulation Of Myoblast Differentiation
Host-mediated Perturbation Of Viral Process
Negative Regulation Of Cell Differentiation
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