SH3KBP1 and SEPTIN6

Number of citations of the paper that reports this interaction (PubMedID 25472714)
0

Data Source:
BioGRID (pull down)

		SH3KBP1	SEPTIN6
Description		SH3 domain containing kinase binding protein 1	septin 6
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Postsynaptic Density Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Anchoring Junction Glutamatergic Synapse GABA-ergic Synapse	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Spindle Cytoskeleton Cilium Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Midbody Septin Complex Motile Cilium Cell Division Site Cleavage Furrow Septin Collar Cell Projection Axon Terminus Sperm Annulus Presynapse
	Molecular Function	Protein Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Molecular Adaptor Activity
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Regulation Of Cell Shape Cell Migration Positive Regulation Of B Cell Activation	Mitotic Cytokinesis Spermatogenesis Intracellular Protein Localization Cell Differentiation Cell Division Cytoskeleton-dependent Cytokinesis
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Platelet count ( 32888494)
Interacting Genes		60 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A EGLN1 GGN GPRASP3 GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MET MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219	15 interacting genes: CDC42EP2 CDC42EP3 CEBPA CRK KDM1A MORN4 NSD3 PLEKHF2 RHOU S100A4 SEPTIN1 SEPTIN2 SEPTIN9 SH3KBP1 TK1
Entrez ID		30011	23157
HPRD ID		02301	06716
Ensembl ID		ENSG00000147010	ENSG00000125354
Uniprot IDs		A0A8V8TNL0 A0A8V8TNT5 A0A8V8TNW8 A0A8V8TP27 A0A8V8TP33 A0A8V8TP40 A0A8V8TP63 A0A8V8TP69 A0A8V8TPM1 A0A8V8TQF6 A0A8V8TQU1 B7Z6E8 Q5JPT2 Q5JPT6 Q96B97	B1AMS2 Q14141 Q541S4 Q548C9
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	2QAG 6UPA 6WBP 7M6J
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Cytosol Phosphotyrosine Residue Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Cytoplasm Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Endocytosis Regulation Of Actin Filament Organization Immune Response-activating Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Insulin Receptor Signaling Pathway Protein Binding Natural Killer Cell Mediated Cytotoxicity Insulin Receptor Substrate Binding Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Cadherin Binding Activation Of Immune Response Natural Killer Cell Mediated Immunity Regulation Of Apoptotic Process Signal Transduction Protein Kinase Binding Regulation Protein Catabolic Process At Postsynapse B Cell Receptor Signaling Pathway Positive Regulation Of Membrane Tubulation Vesicle-mediated Transport Receptor Catabolic Process Regulation Of Signal Transduction Import Into Cell Establishment Of Localization In Cell Regulation Of Supramolecular Fiber Organization Receptor Tyrosine Kinase Binding Positive Regulation Of Cellular Component Biogenesis Epidermal Growth Factor Receptor Signaling Pathway T Cell Activation Viral Budding	Regulation Of Cell Shape Cell Division Site Septin Ring Septin Complex Regulation Of Cell Morphogenesis Organelle Organization Cytoskeleton-dependent Cytokinesis Microtubule Cytoskeleton Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Cytoskeleton Organization GTPase Activity Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Cell Projection Organization GTP Binding Positive Regulation Of Cell Projection Organization Non-motile Cilium Actin Filament-based Process Molecular Adaptor Activity Regulation Of Anatomical Structure Morphogenesis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Actin Filament Polymerization Cytoskeletal Regulatory Protein Binding Histone H3K4 Dimethyltransferase Activity Histone H3K27 Dimethyltransferase Activity Cytoskeleton Regulation Of Cell Projection Assembly Response To Vitamin B2 C/EBP Complex Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Meiotic Metaphase Chromosome Alignment Thymidine Kinase Activity Endomembrane System Rho Protein Signal Transduction Regulation Of Cellular Component Size Actin Filament Organization Small GTPase-mediated Signal Transduction Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity CHOP-C/EBP Complex Regulation Of Stem Cell Proliferation Identical Protein Binding Regulation Of Developmental Process Cerebral Cortex Development Cerebellar Neuron Development Epithelial To Mesenchymal Transition
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