PILRA and FCAR

Number of citations of the paper that reports this interaction (PubMedID 15085135)
0

Data Source:
HPRD (in vitro)

		PILRA	FCAR
Description		paired immunoglobin like type 2 receptor alpha	Fc alpha receptor
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding MHC Class I Protein Binding	IgA Receptor Activity IgA Binding
	Biological Process	Signal Transduction	Neutrophil Mediated Immunity Immune Response-regulating Signaling Pathway Immune Response Positive Regulation Of Neutrophil Apoptotic Process Cellular Response To Interferon-alpha Fc Receptor Signaling Pathway Neutrophil Activation Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Neutrophil degranulation
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Red cell distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Ulcerative colitis ( 28067908)
Interacting Genes		10 interacting genes: DNPH1 FAM114A2 FCAR PAICS PFDN5 PTPN11 PTPN6 SORBS1 TOM1 UROD	6 interacting genes: CD79A FCGR1A LYN OSCAR PILRA PPP2CA
Entrez ID		29992	2204
HPRD ID		05631	00914
Ensembl ID		ENSG00000085514	ENSG00000186431
Uniprot IDs		Q9UKJ1	A0A1P8A760 P24071
PDB IDs		3WUZ 3WV0 4NFB 5XO2 5XOF	1OVZ 1OW0 1UCT 8SKU
Enriched GO Terms of Interacting Partners?		Neutrophil Activation Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Myeloid Leukocyte Activation Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Insulin Receptor Binding Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Response To Insulin Stimulus Carboxy-lyase Activity Regulation Of Lipopolysaccharide-mediated Signaling Pathway Signaling Receptor Complex Adaptor Activity Positive Regulation Of D-glucose Import Regulation Of Type I Interferon-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of D-glucose Transmembrane Transport Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin IgA Receptor Activity RNA Polymerase III Assembly RNA Polymerase I Assembly Epididymis Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of D-glucose Import Uroporphyrinogen Decarboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Myeloid Cell Development Regulation Of Insulin Receptor Signaling Pathway Nucleoside Monophosphate Metabolic Process Negative Regulation Of T Cell Proliferation Regulation Of D-glucose Transmembrane Transport Regulation Of Cellular Response To Insulin Stimulus Specific Granule Membrane RNA Polymerase II Core Complex Assembly Protein Dephosphorylation Intestinal Epithelial Cell Migration Myosin VI Binding 5-hydroxymethyl-dUMP N-hydrolase Activity Immune Effector Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Adhesion Molecule Binding Protein Tyrosine Phosphatase Activity Negative Regulation Of Leukocyte Proliferation IgA Binding	Immune Response-regulating Signaling Pathway Adaptive Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Membrane Raft B Cell Proliferation Fc-gamma Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Leukocyte Differentiation Lymphocyte Homeostasis Signal Transduction Plasma Membrane High-affinity IgG Receptor Activity Leukocyte Homeostasis RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response IgM B Cell Receptor Complex Lymphocyte Proliferation Leukocyte Proliferation Mononuclear Cell Proliferation Immune System Process Regulation Of Immune System Process B Cell Receptor Complex Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Platelet Degranulation Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Myeloid Leukocyte Differentiation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Dendritic Cell Apoptotic Process Homeostasis Of Number Of Cells Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Collagen Receptor Activity B Cell Activation IgG Receptor Activity Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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